Publication detail

Advanced Pharmacokinetic Modeling in Small-Animal Compressed-Sensing DCE-MRI

JIŘÍK, R. MANGOVÁ, M. RAJMIC, P. MACÍČEK, O. SOUČEK, K. STARČUK, Z.

Original Title

Advanced Pharmacokinetic Modeling in Small-Animal Compressed-Sensing DCE-MRI

Type

abstract

Language

English

Original Abstract

To overcome the physical limits of the achievable spatial and temporal resolution in Dynamic Contrast-Enhanced (DCE) MRI, compressed-sensing (CS) techniques have been proposed [1]. So far, CS has been combined only with simpler pharmacokinetic (PK) models (e.g. generalized kinetic model [2]), which do not provide estimates of blood flow, Fb, and permeability-surface area product, PS. To the authors' knowledge, no CS DCE has been shown for advanced PK models, i.e. models providing also estimates of Fb and PS. This is probably because the requirements of these models on temporal resolution and the signal-to- noise ratio (SNR) are much higher than for simple PK models. We use an advanced PK model (adiabatic approximation of the tissue homogeneity model - ATH) in combination with CS, based on a 3D radial golden-angle (GA) stack-of-stars (SOS) acquisition [3] and the L+S reconstruction [4].

Keywords

Compressed sensing; DCE;MRI; GA; golden angle

Authors

JIŘÍK, R.; MANGOVÁ, M.; RAJMIC, P.; MACÍČEK, O.; SOUČEK, K.; STARČUK, Z.

Released

3. 10. 2019

Location

Rotterdam, Netherlands

Pages from

1

Pages to

1

Pages count

1

BibTex

@misc{BUT157846,
  author="Radovan {Jiřík} and Marie {Mangová} and Pavel {Rajmic} and Ondřej {Macíček} and Karel {Souček} and Zenon {Starčuk}",
  title="Advanced Pharmacokinetic Modeling in Small-Animal Compressed-Sensing DCE-MRI",
  booktitle="ESMRMB 2019 - 36th Annual Scientific Meeting",
  year="2019",
  pages="1--1",
  address="Rotterdam, Netherlands",
  note="abstract"
}