Publication detail

Evaluation of aerosol deposition in a realistic human airway model by PET/CT

BŘÍNEK, A. LÁZŇOVSKÝ, J. LÍZAL, F. ŘEHÁK, Z. ZIKMUND, T. JEDELSKÝ, J. JÍCHA, M. KAISER, J.

Original Title

Evaluation of aerosol deposition in a realistic human airway model by PET/CT

Type

article in a collection out of WoS and Scopus

Language

English

Original Abstract

The investigation of the drug delivery into the lungs is essential for the effectiveness determination of their treatment. The numerical models are developed for the theoretical calculation of the particle deposition. The realistic human airway models were manufactured for the evaluation of the theoretical results. The overall drug accumulation is calculated but it is not possible to achieve the local deposition. The combined Positron Emission Tomography and X-ray Computed Tomography (PET/CT) imaging was applied for the local deposition analysis. The new algorithm for the precise identification of the individual section of the airway model in the CT data was created. PET/CT images were employed for the localization of deposited aerosol in the realistic model of the oral cavity and the following seven generation of the tracheobronchial tree. The realistic human airway model and the developed algorithm represent the new method for the precise local deposition of aerosol evaluation in human lungs.

Keywords

Positron Emission Tomography, X-ray Computed Tomography, realistic human airway model, automatic segmentation algorithm

Authors

BŘÍNEK, A.; LÁZŇOVSKÝ, J.; LÍZAL, F.; ŘEHÁK, Z.; ZIKMUND, T.; JEDELSKÝ, J.; JÍCHA, M.; KAISER, J.

Released

28. 2. 2018

Pages count

6

BibTex

@inproceedings{BUT155273,
  author="Adam {Břínek} and Jakub {Lázňovský} and František {Lízal} and Zdeněk {Řehák} and Tomáš {Zikmund} and Jan {Jedelský} and Miroslav {Jícha} and Jozef {Kaiser}",
  title="Evaluation of aerosol deposition in a realistic human airway model by PET/CT",
  year="2018",
  pages="6"
}