Publication detail

Experimental and Theoretical Study of Doxorubicin Physicochemical Interaction with BN(O) Drug Delivery Nanocarriers

PERMYAKOVA, E. ANTIPINA, L. KOVALSKII, A. ZHITNYAK, I. GUDZ, K. POLČÁK, J. SOROKIN, P. MANAKHOV, A. SHTANSKY, D.

Original Title

Experimental and Theoretical Study of Doxorubicin Physicochemical Interaction with BN(O) Drug Delivery Nanocarriers

Type

journal article in Web of Science

Language

English

Original Abstract

Drug-loaded nanocarriers have a great potential for tumor therapy. Such systems must have high drug-loading efficacy in an alkaline medium and effectively release therapeutic agent in an acidic medium of endosomal/lysosomal compartments of tumor cells. Herein, we experimentally and theoretically (using density functional theory) studied the chemical interaction of doxorubicin (DOX) with different boron nitride (BN) surfaces depending on the degree of their oxidation. Three groups of hexagonal BN nano particles (BNNPs) obtained by boron oxide chemical vapor deposition process, i.e., (i) as-synthesized and those after (ii) repeated washing in water and (iii) high-temperature annealing, and their corresponding DOX-BN conjugates were studied. Oxidation of BNNPs significantly improved their interaction with DOX. As a result, the amount of immobilized DOX on the B2O3 surface was higher in comparison with the BNNPs containing little oxygen. The formation of stable DOX-BN conjugates mainly depended on the attraction of electron density in the area of aromatic rings in the highest occupied molecular orbital of DOX. The presence of a protonated NH2 groups in DOX can facilitate electron density transfer from the DOXH+ to the boron oxide surface.

Keywords

BORON-NITRIDE NANOTUBES; CARBON NANOTUBES; IN-VIVO; CHEMOTHERAPY; ACID; NANOPARTICLES; ENCAPSULATION

Authors

PERMYAKOVA, E.; ANTIPINA, L.; KOVALSKII, A.; ZHITNYAK, I.; GUDZ, K.; POLČÁK, J.; SOROKIN, P.; MANAKHOV, A.; SHTANSKY, D.

Released

22. 11. 2018

ISBN

1932-7447

Periodical

Journal of Physical Chemistry C (print)

Year of study

122

Number

46

State

United States of America

Pages from

26409

Pages to

26418

Pages count

10

URL

https://pubs.acs.org/doi/10.1021/acs.jpcc.8b07531

BibTex

@article{BUT152103,
  author="Elizaveta {Permyakova} and Liubov Yu. {Antipina} and Andrey {Kovalskii} and I.Y. {Zhitnyak} and Kristina Yu. {Gudz} and Josef {Polčák} and Pavel B. {Sorokin} and Anton {Manakhov} and Dmitry V. {Shtansky}",
  title="Experimental and Theoretical Study of Doxorubicin Physicochemical Interaction with BN(O) Drug Delivery Nanocarriers",
  journal="Journal of Physical Chemistry C (print)",
  year="2018",
  volume="122",
  number="46",
  pages="26409--26418",
  issn="1932-7447",
  url="https://pubs.acs.org/doi/10.1021/acs.jpcc.8b07531"
}