Publication detail

Changes in Phonation and Their Relations with Progress of Parkinson’s Disease

GALÁŽ, Z. MEKYSKA, J. ZVONČÁK, V. MUCHA, J. KISKA, T. SMÉKAL, Z. ELIÁŠOVÁ, I. MRÁČKOVÁ, M. KOŠŤÁLOVÁ, M. REKTOROVÁ, I. FAÚNDEZ ZANUY, M. ALONSO-HERNANDEZ, J. GOMEZ-VILDA, P.

Original Title

Changes in Phonation and Their Relations with Progress of Parkinson’s Disease

English Title

Changes in Phonation and Their Relations with Progress of Parkinson’s Disease

Type

journal article

Language

en

Original Abstract

Hypokinetic dysarthria, which is associated with Parkinson’s disease (PD), affects several speech dimensions, including phonation. Although the scientific community has dealt with a quantitative analysis of phonation in PD patients, a complex research revealing probable relations between phonatory features and progress of PD is missing. Therefore, the aim of this study is to explore these relations and model them mathematically to be able to estimate progress of PD during a two-year follow-up. We enrolled 51 PD patients who were assessed by three commonly used clinical scales. In addition, we quantified eight possible phonatory disorders in five vowels. To identify the relationship between baseline phonatory features and changes in clinical scores, we performed a partial correlation analysis. Finally, we trained XGBoost models to predict the changes in clinical scores during a two-year follow-up. For two years, the patients’ voices became more aperiodic with increased microperturbations of frequency and amplitude. Next, the XGBoost models were able to predict changes in clinical scores with an error in range 11–26%. Although we identified some significant correlations between changes in phonatory features and clinical scores, they are less interpretable. This study suggests that it is possible to predict the progress of PD based on the acoustic analysis of phonation. Moreover, it recommends utilizing the sustained vowel /i/ instead of /a/.

English abstract

Hypokinetic dysarthria, which is associated with Parkinson’s disease (PD), affects several speech dimensions, including phonation. Although the scientific community has dealt with a quantitative analysis of phonation in PD patients, a complex research revealing probable relations between phonatory features and progress of PD is missing. Therefore, the aim of this study is to explore these relations and model them mathematically to be able to estimate progress of PD during a two-year follow-up. We enrolled 51 PD patients who were assessed by three commonly used clinical scales. In addition, we quantified eight possible phonatory disorders in five vowels. To identify the relationship between baseline phonatory features and changes in clinical scores, we performed a partial correlation analysis. Finally, we trained XGBoost models to predict the changes in clinical scores during a two-year follow-up. For two years, the patients’ voices became more aperiodic with increased microperturbations of frequency and amplitude. Next, the XGBoost models were able to predict changes in clinical scores with an error in range 11–26%. Although we identified some significant correlations between changes in phonatory features and clinical scores, they are less interpretable. This study suggests that it is possible to predict the progress of PD based on the acoustic analysis of phonation. Moreover, it recommends utilizing the sustained vowel /i/ instead of /a/.

Keywords

phonation; acoustic analysis; follow-up study; hypokinetic dysarthria; Parkinson’s disease

Released

22.01.2019

Publisher

MDPI

Pages from

1

Pages to

18

Pages count

18

URL

Full text in the Digital Library

BibTex


@article{BUT151772,
  author="Zoltán {Galáž} and Jiří {Mekyska} and Vojtěch {Zvončák} and Ján {Mucha} and Tomáš {Kiska} and Zdeněk {Smékal} and Ilona {Eliášová} and Martina {Mráčková} and Miroslava {Košťálová} and Irena {Rektorová} and Marcos {Faúndez Zanuy} and Jesus {Alonso-Hernandez} and Pedro {Gomez-Vilda}",
  title="Changes in Phonation and Their Relations with Progress of Parkinson’s Disease",
  annote="Hypokinetic dysarthria, which is associated with Parkinson’s disease (PD), affects several speech dimensions, including phonation. Although the scientific community has dealt with a quantitative analysis of phonation in PD patients, a complex research revealing probable relations between phonatory features and progress of PD is missing. Therefore, the aim of this study is to explore these relations and model them mathematically to be able to estimate progress of PD during a two-year follow-up. We enrolled 51 PD patients who were assessed by three commonly used clinical scales. In addition, we quantified eight possible phonatory disorders in five vowels. To identify the relationship between baseline phonatory features and changes in clinical scores, we performed a partial correlation analysis. Finally, we trained XGBoost models to predict the changes in clinical scores during a two-year follow-up. For two years, the patients’ voices became more aperiodic with increased microperturbations of frequency and amplitude. Next, the XGBoost models were able to predict changes in clinical scores with an error in range 11–26%. Although we identified some significant correlations between changes in phonatory features and clinical scores, they are less interpretable. This study suggests that it is possible to predict the progress of PD based on the acoustic analysis of phonation. Moreover, it recommends utilizing the sustained vowel /i/ instead of /a/.",
  address="MDPI",
  chapter="151772",
  doi="10.3390/app8122339",
  howpublished="online",
  institution="MDPI",
  number="12",
  volume="8",
  year="2019",
  month="january",
  pages="1--18",
  publisher="MDPI",
  type="journal article"
}