Project - Cell-specific editing of CXCR4 gene mediated by CRISPR/Cas9 on layered onion nanoparticles in HER2 positive breast cancer cells

Funding resources

Brno University of Technology - Vnitřní projekty VUT

- whole funder (2021-01-01 - 2022-12-31)

On the project

CRISPR/Cas9 has its challenges. There is no technology delivering delivering CRISPR/Cas9 in a cell-specific manner even though it is desirable to edit genes only in target cells and not elsewhere. This applies especially in cancer. In this project, I will be constructing layered nanoparticle with advanced properties delivering CRISPR/Cas9 cell specifically into HER2+ breast cancer cells and knocking-out CXCR4 gene, which is overexpressed in HER2+ breast cancer causing aggressive phenotype and the formation of metastasis.

Mark

CEITEC VUT-J-21-7506

Default language

Czech

People responsible

Heger Zbyněk, doc. - fellow researcher
Ressnerová Alžběta, M.Sc., MSc - principal person responsible

Units

Central European Institute of Technology BUT
- (2021-01-01 - 2021-12-31)
Smart Nanodevices
- (2021-01-01 - 2021-12-31)

Responsibility: Ressnerová Alžběta, M.Sc., MSc

VUT

Faculties

University Institutes

Parts

Cell-specific editing of CXCR4 gene mediated by CRISPR/Cas9 on layered onion nanoparticles in HER2 positive breast cancer cells