Detail publikace

Transport aerosolu v modelu lidských plic

LÍZAL, F. JEDELSKÝ, J. LIPPAY, J. HALASOVÁ, T. MRAVEC, F. JÍCHA, M.

Originální název

Aerosol Transport in a Model of Human Lungs

Český název

Transport aerosolu v modelu lidských plic

Anglický název

Aerosol Transport in a Model of Human Lungs

Typ

článek ve sborníku

Jazyk

en

Originální abstrakt

Complex flow structures emerging in human lungs significantly affect deposition of inhaled particles. Therefore flow measurements alongside with deposition measurements have to be performed on the same model geometry. Amount of deposited aerosol particles in different regions of lungs could be measured by several methods. Gamma detection of radioactive tagged particles is subjected to strict regulations and is expensive; gravimetry and fluorometry are thus preferred in current studies. Novel methodology for fluorometric measurement of aerosol transport in models of human lungs was developed. Some previously published experiments were performed using condensation of di(2-ethylhexyl) sebacate (DEHS) vapours on fluorescein nuclei. Their authors assumed that fluorescein is necessary for generation of fluorescent particles and they neglected possible fluorescence of DEHS itself. Our analysis of DEHS characteristics indicated that DEHS fluorescence could be detected apart in sufficient rate to evaluate aerosol deposition. Consequently experiments in standard setup of condensation monodisperse aerosol generator with sodium chloride nuclei instead of fluorescein were performed. Results demonstrating applicability and limitations of DEHS particles for fluorometric deposition measurements are presented and discussed.

Český abstrakt

Složité struktury proudění, které se vyvíjejí v lidských dýchacích cestách, ovlivňují depozici vdechovaných částic. Článek se zabývá použitím fluorometrické metody pro měření depozice částic aerosolu, konkrétně možností využití fluorescence di-2-ethyl hexyl sebacatu (DEHS) pro fluorescenční měření. Jsou prezentovány experimenty potvrzující fluorescenční vlastnosti DEHS a limity jeho použití.

Anglický abstrakt

Complex flow structures emerging in human lungs significantly affect deposition of inhaled particles. Therefore flow measurements alongside with deposition measurements have to be performed on the same model geometry. Amount of deposited aerosol particles in different regions of lungs could be measured by several methods. Gamma detection of radioactive tagged particles is subjected to strict regulations and is expensive; gravimetry and fluorometry are thus preferred in current studies. Novel methodology for fluorometric measurement of aerosol transport in models of human lungs was developed. Some previously published experiments were performed using condensation of di(2-ethylhexyl) sebacate (DEHS) vapours on fluorescein nuclei. Their authors assumed that fluorescein is necessary for generation of fluorescent particles and they neglected possible fluorescence of DEHS itself. Our analysis of DEHS characteristics indicated that DEHS fluorescence could be detected apart in sufficient rate to evaluate aerosol deposition. Consequently experiments in standard setup of condensation monodisperse aerosol generator with sodium chloride nuclei instead of fluorescein were performed. Results demonstrating applicability and limitations of DEHS particles for fluorometric deposition measurements are presented and discussed.

Klíčová slova

depozice aerosolu, DEHS, model plic

Rok RIV

2011

Vydáno

22.11.2011

Nakladatel

Technical University of Liberec

Místo

Liberec, Czech Republic

ISBN

978-80-7372-784-0

Kniha

Experimental Fluid Mechanics 2011 Conference Proceedings Volume 1

Strany od

281

Strany do

288

Strany počet

9

BibTex


@inproceedings{BUT92795,
  author="František {Lízal} and Jan {Jedelský} and Josef {Lippay} and Tereza {Venerová} and Filip {Mravec} and Miroslav {Jícha}",
  title="Aerosol Transport in a Model of Human Lungs",
  annote="Complex flow structures emerging in human lungs significantly affect deposition of inhaled particles. Therefore flow measurements alongside with deposition measurements have to be performed on the same model geometry. Amount of deposited aerosol particles in different regions of lungs could be measured by several methods. Gamma detection of radioactive tagged particles is subjected to strict regulations and is expensive; gravimetry and fluorometry are thus preferred in current studies.
Novel methodology for fluorometric measurement of aerosol transport in models of human lungs was developed. Some previously published experiments were performed using condensation of di(2-ethylhexyl) sebacate (DEHS) vapours on fluorescein nuclei. Their authors assumed that fluorescein is necessary for generation of fluorescent particles and they neglected possible fluorescence of DEHS itself. Our analysis of DEHS characteristics indicated that DEHS fluorescence could be detected apart in sufficient rate to evaluate aerosol deposition. Consequently experiments in standard setup of condensation monodisperse aerosol generator with sodium chloride nuclei instead of fluorescein were performed. Results demonstrating applicability and limitations of DEHS particles for fluorometric deposition measurements are presented and discussed.",
  address="Technical University of Liberec",
  booktitle="Experimental Fluid Mechanics 2011 Conference Proceedings Volume 1",
  chapter="92795",
  howpublished="print",
  institution="Technical University of Liberec",
  year="2011",
  month="november",
  pages="281--288",
  publisher="Technical University of Liberec",
  type="conference paper"
}