Detail publikace

Is the reliability of wastewater-based epidemiology affected by season? Comparative analysis with pharmaceuticals prescriptions

CARNEVALE MIINO, M. MACSEK, T. HALEŠOVÁ, T. CHORAZY, T. HLAVÍNEK, P.

Originální název

Is the reliability of wastewater-based epidemiology affected by season? Comparative analysis with pharmaceuticals prescriptions

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Wastewater-based epidemiology (WBE) has been already proposed by several authors for estimating the consumption of drugs, mainly the illicit ones. However, not much information is available about the actual reliability of this tool given the absence of comparison with the actual consumption. This work aims to evaluate the reliability of the WBE as a tool for estimating the consumption of pharmaceuticals in urban area. Measured consumption back-calculated with a WBE approach was compared with prescription of pharmaceutical products as “control.” Moreover, seasonal influence on (i) pharmaceutical consumption, (ii) load of pharmaceutical products in the sewer system, and (iii) reliability of WBE was evaluated. Ciprofloxacin, sulfamethoxazole, metoprolol, carbamazepine, and citalopram were estimated by WBE with a difference respect to the “control” value lower than 0.2 order of magnitude while only trimethoprim and sotalol exceeded the 0.5 order of magnitude of difference but below the 1 order of magnitude. Sedatives were the best represented by WBE (on average 0.15 order of magnitude of difference compared to prescription data). However, further studies are suggested to fully estimate the influence of the type of APs on the reliability of the WBE. Seasonal patterns were found for the load of ciprofloxacin in the sewer and for the consumption of sulfamethoxazole and trimethoprim by population but seasonal changes did not have a significant impact (p > 0.05) on the reliability of WBE. Despite some gaps remained to optimize the reliability of the tool, WBE can be considered a valid method to estimate the consumption of prescribed drugs from the analysis of the sewer system.

Klíčová slova

Wastewater Based Epidemiology (WBE); Wastewater treatment plant; Emerging contaminants; Drug consumption; Pharmaceutical products; Seasonal patterns

Autoři

CARNEVALE MIINO, M.; MACSEK, T.; HALEŠOVÁ, T.; CHORAZY, T.; HLAVÍNEK, P.

Vydáno

5. 2. 2024

Nakladatel

Springer-Verlag

Místo

Berlin, Germany

ISSN

1614-7499

Periodikum

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Ročník

31

Číslo

7

Stát

Spolková republika Německo

Strany počet

11

URL

https://link.springer.com/article/10.1007/s11356-024-32110-w#Fun

BibTex

@article{BUT187741,
  author="Marco {Carnevale Miino} and Tomáš {Macsek} and Taťána {Halešová} and Tomáš {Chorazy} and Petr {Hlavínek}",
  title="Is the reliability of wastewater-based epidemiology affected by season? Comparative analysis with pharmaceuticals prescriptions",
  journal="ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH",
  year="2024",
  volume="31",
  number="7",
  pages="11",
  doi="10.1007/s11356-024-32110-w",
  issn="1614-7499",
  url="https://link.springer.com/article/10.1007/s11356-024-32110-w#Fun"
}