Detail publikace

Haloperidol Cytotoxicity and Its Relation to Oxidative Stress

RAUDENSKÁ, M. GUMULEC, J. BABULA, P. STRAČINA, T. SZTALMACHOVÁ, M. POLANSKÁ, H. ADAM, V. KIZEK, R. NOVÁKOVÁ, M. MASAŘÍK, M.

Originální název

Haloperidol Cytotoxicity and Its Relation to Oxidative Stress

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Haloperidol (HP) is used for the symptomatic treatment of psychosis, manic phases, hyperactivity, aggressiveness, and acute delirium. Long-term use leads to various adverse side effects, especially to severe impairment of extrapyramidal nerve tracts and in particular, altered QT interval and increased incidence of arrhytmias. It is believed that cytotoxicity of HP and its metabolites is responsible for both neurotoxicity and cardiotoxicity. Extrapyramidal and cardiac adverse side effects may be explained by the HP-induced oxidative stress, as implicated by many studies. HP was reported to induce lipid peroxidation with subsequent membrane changes, responsible for cell death. Vice versa, cells resistant to oxidative stress are also resistant to the toxic effects of HP. Similarly, high percentage of patients suffering from extrapyramidal symptoms treated by vitamin E and other lipid-soluble antioxidants demonstrates diminishing of these adverse side effects. HP's ability to induce oxidative stress by multi-modal action (increased metabolism of dopamine, decrease of glutathione content, induction of NF-kappa B transcription factor, and inhibition of complex I of respiratory chain) has been established just recently. This review brings summarizing view on the cytotoxicity of haloperidol and involvement of reactive oxygen species and oxidative stress HP-induced cytotoxicity.

Klíčová slova

Arrhytmia; cardiotoxicity; dopamine; haloperidol; oxidative stress; Torsade de Pointes

Autoři

RAUDENSKÁ, M.; GUMULEC, J.; BABULA, P.; STRAČINA, T.; SZTALMACHOVÁ, M.; POLANSKÁ, H.; ADAM, V.; KIZEK, R.; NOVÁKOVÁ, M.; MASAŘÍK, M.

Vydáno

1. 12. 2013

ISSN

1389-5575

Periodikum

MINI-REVIEWS IN MEDICINAL CHEMISTRY

Ročník

13

Číslo

14

Stát

Stát Spojené arabské emiráty

Strany od

1993

Strany do

1998

Strany počet

6

BibTex

@article{BUT142306,
  author="Martina {Raudenská} and Jaromír {Gumulec} and Petr {Babula} and Tibor {Stračina} and Markéta {Sztalmachová} and Hana {Polanská} and Vojtěch {Adam} and René {Kizek} and Marie {Nováková} and Michal {Masařík}",
  title="Haloperidol Cytotoxicity and Its Relation to Oxidative Stress",
  journal="MINI-REVIEWS IN MEDICINAL CHEMISTRY",
  year="2013",
  volume="13",
  number="14",
  pages="1993--1998",
  issn="1389-5575"
}