Detail publikace

Peptide modified carbon nanotubes for drug delivery

MILOSAVLJEVIĆ, V. KREJČOVÁ, L. GURÁŇ, R. SKALIČKOVÁ, S. BUCHTELOVÁ, H. MOULICK, A. KOPEL, P. ADAM, V.

Originální název

Peptide modified carbon nanotubes for drug delivery

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

Multi-walled-carbon nanotubes (MWCNTs) are widely explored as carriers for drug delivery, due to their facile transport through cellular membranes, and are reportedly found to be effective against cancer. In the present study, we have designed a MWCNTs nanocarrier for doxorubicin delivery to prostate cancer tissue. The cell penetrating peptide (SMSIALR) modified MWCNTs provide better penetration of nanocarrier into cancer cells. Using fluorescence measurement, the doxorubicin (DOXO) binding efficiency was estimated to 100%. MALDI analysis confirms the presence of doxorubicin and peptide on the MWCNTsstructure. The stability behavior of the colloid suspension indicates the positive charge of carbon nanocarrier and due to this fact, the cancer cells membranes carry negative charge, the MWCNTs is established as suitable drug delivery system for doxorubicin.

Klíčová slova

Multiwall carbon nanotubes; Cell penetrating peptides; Doxorubicin; Drug delivery

Autoři

MILOSAVLJEVIĆ, V.; KREJČOVÁ, L.; GURÁŇ, R.; SKALIČKOVÁ, S.; BUCHTELOVÁ, H.; MOULICK, A.; KOPEL, P.; ADAM, V.

Vydáno

9. 11. 2016

Nakladatel

Mendel University in Brno

Místo

Brno, Czech Republic

ISBN

978-80-7509-443-8

Kniha

MendelNet2016

Strany od

999

Strany do

1004

Strany počet

6

BibTex

@inproceedings{BUT138110,
  author="Vedran {Milosavljević} and Ludmila {Krejčová} and Roman {Guráň} and Sylvie {Skaličková} and Hana {Michálková} and Amitava {Moulick} and Pavel {Kopel} and Vojtěch {Adam}",
  title="Peptide modified carbon nanotubes for drug delivery",
  booktitle="MendelNet2016",
  year="2016",
  pages="999--1004",
  publisher="Mendel University in Brno",
  address="Brno, Czech Republic",
  isbn="978-80-7509-443-8"
}