Detail publikace

Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges

GANDALOVIČOVÁ, A. RÖSEL, D. FERNANDES, M. VESELÝ, P. HENEBERG, P. ČERMÁK, V. PETRUŽELKA, L. KUMAR, S. SANZ-MORENO, V. BRÁBEK, J.

Originální název

Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

In solid cancers, invasion and metastasis account for more than 90% of mortality. However, in the current armory of anticancer therapies, a specific category of anti-invasion and antimetastatic drugs is missing. Here, we coin the term ‘migrastatics’ for drugs interfering with all modes of cancer cell invasion and metastasis, to distinguish this class from conventional cytostatic drugs, which are mainly directed against cell proliferation. We define actin polymerization and contractility as target mechanisms for migrastatics, and review candidate migrastatic drugs. Critical assessment of these antimetastatic agents is warranted, because they may define new options for the treatment of solid cancers.

Klíčová slova

solid cancer; metastasis; invasion; treatment; contractility; migrastatics

Autoři

GANDALOVIČOVÁ, A.; RÖSEL, D.; FERNANDES, M.; VESELÝ, P.; HENEBERG, P.; ČERMÁK, V.; PETRUŽELKA, L.; KUMAR, S.; SANZ-MORENO, V.; BRÁBEK, J.

Vydáno

1. 6. 2017

Nakladatel

Elsevier

ISSN

2405-8033

Periodikum

Trends in Cancer

Ročník

3

Číslo

6

Stát

Spojené státy americké

Strany od

391

Strany do

406

Strany počet

16

URL

https://www.cell.com/trends/cancer/abstract/S2405-8033(17)30085-7

Plný text v Digitální knihovně

http://hdl.handle.net/11012/84149

BibTex

@article{BUT136334,
  author="Aneta {Gandalovičová} and Daniel {Rösel} and Michael {Fernandes} and Pavel {Veselý} and Petr {Henenberg} and Vladimír {Čermák} and Luboš {Petruželka} and Sunil {Kumar} and Victoria {Sanz-Moreno} and Jan {Brábek}",
  title="Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges",
  journal="Trends in Cancer",
  year="2017",
  volume="3",
  number="6",
  pages="391--406",
  doi="10.1016/j.trecan.2017.04.008",
  issn="2405-8033",
  url="https://www.cell.com/trends/cancer/abstract/S2405-8033(17)30085-7"
}