Detail publikace

Rabbit antithymocyte globulin–induced serum sickness disease and human kidney graft survival

Couvrat-Desvergnes, G. Salama, A. Le Berre, L Evanno, G. Viklicky, O. Hruba, P. Vesely, P. Guerif, P Dejoie, T. Rousse, J. Nicot, A. Bach, JM. Ang, E. Foucher, Y. Brouard, S. Castagnet, S. Giral, M. Harb, J. Perreault, H. Charreau, B. Lorent, M. Soulillou, JP

Originální název

Rabbit antithymocyte globulin–induced serum sickness disease and human kidney graft survival

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Rabbit-generated antithymocyte globulins (ATGs), which target human T cells, are widely used as immunosuppressive agents during treatment of kidney allograft recipients. However, ATGs can induce immune complex diseases, including serum sickness disease (SSD). Rabbit and human IgGs have various antigenic differences, including expression of the sialic acid Neu5Gc and α-1-3-Gal (Gal), which are not synthesized by human beings. Moreover, anti-Neu5Gc antibodies have been shown to preexist and be elicited by immunization in human subjects. This study aimed to assess the effect of SSD on long-term kidney allograft outcome and to compare the immunization status of grafted patients presenting with SSD following ATG induction treatment.

Klíčová slova

Rabbit antithymocyte globulin; serum sickness disease

Autoři

Couvrat-Desvergnes, G.; Salama, A.; Le Berre, L; Evanno, G.; Viklicky, O.; Hruba, P.; Vesely, P.; Guerif, P; Dejoie, T.; Rousse, J.; Nicot, A.; Bach, JM. ; Ang, E.; Foucher, Y.; Brouard, S.; Castagnet, S.; Giral, M.; Harb, J.; Perreault, H.; Charreau, B.; Lorent, M.; Soulillou, JP

Rok RIV

2015

Vydáno

1. 12. 2015

ISSN

0021-9738

Periodikum

JOURNAL OF CLINICAL INVESTIGATION

Ročník

125

Číslo

12

Stát

Spojené státy americké

Strany od

4655

Strany do

4665

Strany počet

11

BibTex

@article{BUT120517,
  author="Couvrat-Desvergnes, G. and Salama, A. and Le Berre, L and Evanno, G. and Viklicky, O. and Hruba, P. and Vesely, P. and Guerif, P and Dejoie, T. and Rousse, J. and Nicot, A. and Bach, JM. and Ang, E. and Foucher, Y. and Brouard, S. and Castagnet, S. and Giral, M. and Harb, J. and Perreault, H. and Charreau, B. and Lorent, M. and Soulillou, JP",
  title="Rabbit antithymocyte globulin–induced serum sickness disease and human kidney graft survival",
  journal="JOURNAL OF CLINICAL INVESTIGATION",
  year="2015",
  volume="125",
  number="12",
  pages="4655--4665",
  doi="10.1172/JCI82267",
  issn="0021-9738"
}