Detail publikace

Metallothionein polymorphisms in pathological processes

RAUDENSKÁ, M. GUMULEC, J. PODLAHA, O. SZTALMACHOVÁ, M. BABULA, P. ECKSCHLAGER, T. ADAM, V. KIZEK, R. MASAŘÍK, M.

Originální název

Metallothionein polymorphisms in pathological processes

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Metallothioneins (MTs) are a class of metal-binding proteins characterized by a high cysteine content and low molecular weight. MTs play an important role in metal metabolism and protect cells against the toxic effects of radiation, alkylating agents and oxygen free radicals. The evidence that individual genetic characteristics of MTs play an important role in physiological and pathological processes associated with antioxidant defense and detoxification inspired targeted studies of genetic polymorphisms in a clinical context. In recent years, common MT polymorphisms were identified and associated with, particularly, western lifestyle diseases such as cancer, complications of atherosclerosis, and type 2 diabetes mellitus along with related complications.This review summarizes all evidence regarding MT polymorphisms of major human MTs (MT1, MT2, MT3 and MT4), their relation to pathological processes, and outlines specific applications of MTs as a set of genetic markers for certain pathologies.

Klíčová slova

Metallothionein, pathological processes, protein

Autoři

RAUDENSKÁ, M.; GUMULEC, J.; PODLAHA, O.; SZTALMACHOVÁ, M.; BABULA, P.; ECKSCHLAGER, T.; ADAM, V.; KIZEK, R.; MASAŘÍK, M.

Rok RIV

2014

Vydáno

1. 1. 2014

ISSN

1756-5901

Periodikum

METALLOMICS

Ročník

6

Číslo

1

Stát

Spojené království Velké Británie a Severního Irska

Strany od

55

Strany do

68

Strany počet

14

BibTex

@article{BUT106911,
  author="Martina {Raudenská} and Jaromír {Gumulec} and Ondřej {Podlaha} and Markéta {Sztalmachová} and Petr {Babula} and Tomáš {Eckschlager} and Vojtěch {Adam} and René {Kizek} and Michal {Masařík}",
  title="Metallothionein polymorphisms in pathological processes",
  journal="METALLOMICS",
  year="2014",
  volume="6",
  number="1",
  pages="55--68",
  doi="10.1039/c3mt00132f",
  issn="1756-5901"
}