Detail publikace

Glutathione Modified Gold Nanoelectrodes and Electrochemical Characterization

HRDÝ, R. HUBÁLEK, J. VRBOVÁ, E. DRBOHLAVOVÁ, J. KYNCLOVÁ, H. SVATOŠ, V.

Originální název

Glutathione Modified Gold Nanoelectrodes and Electrochemical Characterization

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

The gold nanomaterials are used extensively in biosensors due to their biocompatibility as well as high effective surface area. Ordered arrays of gold nanostructure materials have exceptional potential to increase the sensitivity of biosensors. We demonstrated the one of low cost technique, how to prepared biosensor based on vertically aligned gold nanorods (NRs) array, which was fabricated by pulsed electrodeposition method. The advantages of sensing interfaces that contain Au NRs networks are the increased surface area for sensing, improved electrical connectivity through the Au NRs network, and chemical accessibility to the analyte through these networks compared to sensing interfaces based on flat Au surfaces. The next advantage is an electrocatalysis. A biosensor is an analytical tool that fulfills two functions, [1] capturing biological targets and [2] transducing target binding events to measurable signals. One of the linkers for biomolecule binding to sensitive part of biosensor is glutathione (GSH), a very attractive biomolecule for sensors application due to Au-SH binding capability, bio-selectivity and high sensitivity to heavy metal ions. The combination of GSH and nanostructured surfaces could bring many new benefits. EIS (electrochemical impedance spectroscopy) has been employed to characterize the glutathione monolayer assembled on nanostructured gold electrodes. The EIS measurements of surfaces with various nanoparticles geometry have shown the changes of surface properties during the adsorption process of glutathione GSH. According to the simple equivalent electric network of the electrochemical interface; the EIS parameters were also obtained. The results showed that the proposed method should be used in wider application in biochemistry.

Klíčová slova

Biosensor, nanowires, gluthatione

Autoři

HRDÝ, R.; HUBÁLEK, J.; VRBOVÁ, E.; DRBOHLAVOVÁ, J.; KYNCLOVÁ, H.; SVATOŠ, V.

Rok RIV

2013

Vydáno

9. 9. 2013

ISBN

978-80-7375-757-1

Kniha

Sborník příspěvků XIII. Pracovní setkání fyzikálních chemiků a elektrochemiků

Strany od

64

Strany do

65

Strany počet

2

BibTex

@inproceedings{BUT102871,
  author="Radim {Hrdý} and Jaromír {Hubálek} and Eva {Vrbová} and Jana {Drbohlavová} and Hana {Kynclová} and Vojtěch {Svatoš}",
  title="Glutathione Modified Gold Nanoelectrodes and Electrochemical Characterization",
  booktitle="Sborník příspěvků XIII. Pracovní setkání fyzikálních chemiků a elektrochemiků",
  year="2013",
  pages="64--65",
  isbn="978-80-7375-757-1"
}