Detail publikace

Square wave voltammetry as a tool for study of ellipticine-DNA interaction

MASAŘÍK,M. HÚSKA,D. ADAM,V. HUBALEK,J. PROVAZNÍK, I. TRNKOVÁ,L. ECKSCHLAGER,T. STIBOROVÁ,M. KIZEK,R.

Originální název

Square wave voltammetry as a tool for study of ellipticine-DNA interaction

Typ

abstrakt

Jazyk

angličtina

Originální abstrakt

Ellipticine and its derivates belong to prototype compounds acting predominantly by DNA-damaging mechanisms and serving as cytostaic agents. The aim of this work was to study the intercalation of the ellipticine into DNA. For this purpose we utilized adsorptive transfer stripping technique (AdTS) coupled with square wave voltammetry (SWV). Primarily, we investigated the influence of ellipticine on genomic DNA electrochemical signals. Decrease in redox signal of cytosine/adenine (at -1.4 V) was observed as a result of ellipticine intercalation into DNA. The decrease was proportional to increasing concentration of ellipticine.

Klíčová slova

Ellipticine, DNA

Autoři

MASAŘÍK,M.; HÚSKA,D.; ADAM,V.; HUBALEK,J.; PROVAZNÍK, I.; TRNKOVÁ,L.; ECKSCHLAGER,T.; STIBOROVÁ,M.; KIZEK,R.

Vydáno

1. 1. 2010

Nakladatel

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

ISSN

1107-3756

Periodikum

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Ročník

26

Číslo

1

Stát

Spojené státy americké

Strany od

S46

Strany do

S46

Strany počet

1