Detail publikace

Square wave voltammetry as a tool for study of ellipticine-DNA interaction

MASAŘÍK,M. HÚSKA,D. ADAM,V. HUBALEK,J. PROVAZNÍK, I. TRNKOVÁ,L. ECKSCHLAGER,T. STIBOROVÁ,M. KIZEK,R.

Originální název

Square wave voltammetry as a tool for study of ellipticine-DNA interaction

Anglický název

Square wave voltammetry as a tool for study of ellipticine-DNA interaction

Jazyk

en

Originální abstrakt

Ellipticine and its derivates belong to prototype compounds acting predominantly by DNA-damaging mechanisms and serving as cytostaic agents. The aim of this work was to study the intercalation of the ellipticine into DNA. For this purpose we utilized adsorptive transfer stripping technique (AdTS) coupled with square wave voltammetry (SWV). Primarily, we investigated the influence of ellipticine on genomic DNA electrochemical signals. Decrease in redox signal of cytosine/adenine (at -1.4 V) was observed as a result of ellipticine intercalation into DNA. The decrease was proportional to increasing concentration of ellipticine.

Anglický abstrakt

Ellipticine and its derivates belong to prototype compounds acting predominantly by DNA-damaging mechanisms and serving as cytostaic agents. The aim of this work was to study the intercalation of the ellipticine into DNA. For this purpose we utilized adsorptive transfer stripping technique (AdTS) coupled with square wave voltammetry (SWV). Primarily, we investigated the influence of ellipticine on genomic DNA electrochemical signals. Decrease in redox signal of cytosine/adenine (at -1.4 V) was observed as a result of ellipticine intercalation into DNA. The decrease was proportional to increasing concentration of ellipticine.

Dokumenty

BibTex


@misc{BUT93601,
  author="Michal {Masařík} and Dalibor {Húska} and Jaromír {Hubálek} and Ivo {Provazník} and Libuše {Trnková} and René {Kizek}",
  title="Square wave voltammetry as a tool for study of ellipticine-DNA interaction",
  annote="Ellipticine and its derivates belong to prototype compounds acting predominantly by DNA-damaging mechanisms and serving as cytostaic agents. The aim of this work was to study the intercalation of the ellipticine into DNA. For this purpose we utilized adsorptive transfer stripping technique (AdTS) coupled with square wave voltammetry (SWV). Primarily, we investigated the influence of ellipticine on genomic DNA electrochemical signals. Decrease in redox signal of cytosine/adenine (at -1.4 V) was observed as a result of ellipticine intercalation into DNA. The decrease was proportional to increasing concentration of ellipticine.",
  address="INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE",
  chapter="93601",
  institution="INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE",
  number="1",
  year="2010",
  month="january",
  pages="S46--S46",
  publisher="INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE",
  type="abstract"
}