Detail publikace

Modelling the cardiac transverse-axial tubular system

PÁSEK, M. ŠIMURDA, J. CHRISTÉ, G. ORCHARD, C.

Originální název

Modelling the cardiac transverse-axial tubular system

Typ

článek v časopise - ostatní, Jost

Jazyk

angličtina

Originální abstrakt

The transverse-axial tubular system (TATS) of cardiac ventricular myocytes is a complex network of tubules that arises as invaginations of the surface membrane; it appears to form a specialised region of cell membrane that is particularly important for excitation-contraction coupling. However much remains unknown about the structure and role of the TATS. In this brief review we use experimental data and computer modelling to address the following key questions: (i) What fraction of the cell membrane is within the TATS? (ii) Is the composition of the TATS membrane the same as the surface membrane? (iii) How good is electrical coupling between the surface and TATS membranes? (iv) What fraction of each current is within the TATS? (v) How important is the complex structure of the TATS network? (vi) What is the effect of current inhomogeneity on lumenal ion concentrations? (vii) Does the TATS contribute to the functional changes observed in heart failure? Although there are many areas in which experimental evidence is lacking, computer models provide a method to assess and predict the possible function of the TATS; such models suggest that although the surface and TATS membranes are electrically well coupled, concentration of ion flux pathways within the TATS, coupled to restricted diffusion, may result in the ionic composition in the TATS lumen being different from that in the bulk extracellular space, and varying with activity and in pathological conditions.

Klíčová slova

t-tubules; TATS; Heart; Calcium; Ventricle; Computer model

Autoři

PÁSEK, M.; ŠIMURDA, J.; CHRISTÉ, G.; ORCHARD, C.

Rok RIV

2008

Vydáno

1. 4. 2008

ISSN

0079-6107

Periodikum

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Ročník

2008 (96)

Číslo

1-3

Stát

Spojené království Velké Británie a Severního Irska

Strany od

226

Strany do

243

Strany počet

18

BibTex

@article{BUT45342,
  author="Michal {Pásek} and Jiří {Šimurda}",
  title="Modelling the cardiac transverse-axial tubular system",
  journal="PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY",
  year="2008",
  volume="2008 (96)",
  number="1-3",
  pages="226--243",
  issn="0079-6107"
}