Detail publikace

Relative entropy is an easy-to-use invasive electroencephalographic biomarker of the epileptogenic zone

TRÁVNÍČEK, V. KLIMEŠ, P. CIMBÁLNÍK, J. HALÁMEK, J. JURÁK, P. BRINKMANN, B. BALZEKAS, I. ABDOULAH, C. DUBEAU, F. WORRELL, G. BRÁZDIL, M.

Originální název

Relative entropy is an easy-to-use invasive electroencephalographic biomarker of the epileptogenic zone

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Objective: High-frequency oscillations are considered among the most promising interictal biomarkers of the epileptogenic zone in patients suffering from pharmacoresistant focal epilepsy. However, there is no clear definition of pathological high-frequency oscillations, and the existing detectors vary in methodology, performance, and computational costs. This study proposes relative entropy as an easy-to-use novel interictal biomarker of the epileptic tissue.Methods: We evaluated relative entropy and high-frequency oscillation biomarkers on intracranial electroencephalographic data from 39 patients with seizure-free postoperative outcome (Engel Ia) from three institutions. We tested their capability to localize the epileptogenic zone, defined as resected contacts located in the seizure onset zone. The performance was compared using areas under the receiver operating curves (AUROCs) and precision-recall curves. Then we tested whether a universal threshold can be used to delineate the epileptogenic zone across patients from different institutions.Results: Relative entropy in the ripple band (80-250 Hz) achieved an average AUROC of .85. The normalized high-frequency oscillation rate in the ripple band showed an identical AUROC of .85. In contrast to high-frequency oscillations, relative entropy did not require any patient-level normalization and was easy and fast to calculate due to its clear and straightforward definition. One threshold could be set across different patients and institutions, because relative entropy is independent of signal amplitude and sampling frequency.Significance: Although both relative entropy and high-frequency oscillations have a similar performance, relative entropy has significant advantages such as straightforward definition, computational speed, and universal interpatient threshold, making it an easy-to-use promising biomarker of the epileptogenic zone.

Klíčová slova

drug-resistant epilepsy; iEEG; SOZ localization

Autoři

TRÁVNÍČEK, V.; KLIMEŠ, P.; CIMBÁLNÍK, J.; HALÁMEK, J.; JURÁK, P.; BRINKMANN, B.; BALZEKAS, I.; ABDOULAH, C.; DUBEAU, F.; WORRELL, G.; BRÁZDIL, M.

Vydáno

10. 2. 2023

Nakladatel

WILEY

Místo

HOBOKEN

ISSN

0013-9580

Periodikum

EPILEPSIA

Ročník

64

Číslo

4

Stát

Spojené státy americké

Strany od

962

Strany do

972

Strany počet

11

URL

https://onlinelibrary.wiley.com/doi/10.1111/epi17539

BibTex

@article{BUT184402,
  author="Vojtěch {Trávníček} and Petr {Klimeš} and Jan {Cimbálník} and Josef {Halámek} and Pavel {Jurák} and Benjamin H. {Brinkmann} and Irena {Balzekas} and Chifaou {Abdoulah} and Francois {Dubeau} and Gregory {Worrell} and Milan {Brázdil}",
  title="Relative entropy is an easy-to-use invasive electroencephalographic biomarker of the epileptogenic zone",
  journal="EPILEPSIA",
  year="2023",
  volume="64",
  number="4",
  pages="962--972",
  doi="10.1111/epi.17539",
  issn="0013-9580",
  url="https://onlinelibrary.wiley.com/doi/10.1111/epi17539"
}