Detail publikace

Anti-myeloma pro-apoptotic Pt(II) diiodido complexes

MASARYK, L. WEISER DROZDKOVÁ, D. SLOCZYNSKA, K. MONCOL, J. MILDE, D. KRIKAVOVA, R. POPIOL, J. PEKALA, E. ONDRUŠKOVÁ, K. NEMEC, I. SMEŠNÝ, K. ŠTARHA, P.

Originální název

Anti-myeloma pro-apoptotic Pt(II) diiodido complexes

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Platinum-based agents unwaveringly hold their prominent position in cancer treatment. Current research emphasizes finding novel complexes for hard-to-treat cancers with minimum side effects, capable of overcoming resistance. This work presents easy-to-prepare diiodidoplatinum(II) complexes cis-[PtI2(L-n)(2)] (1-7) with imidazole derivatives (L-n), which were considerably effective against multiple myeloma cell lines U266B1 and KMS12-PE. The leading compound 6 (at 3 mu M concentration) extraordinarily reduced viability of U266B1 and KMS12-PE myeloma cells to 3.0% and 1.1%, respectively, and exceeded the conventional platinum-based anticancer drug cisplatin (93.1% and 88.3%, respectively) that is used clinically for the combination therapy of multiple myeloma. Complex 6 was significantly more effective in inducing apoptosis in KMS12-PE cells without interleukin-6 (IL-6) expression than in U266B1 cells with IL-6 expression. Complex 6 also induced apoptosis in co-culture of KMS12-PE with non-cancerous stromal fibroblasts (HS-5), and displayed markedly lower activity in the HS-5 stromal fibroblast cells than in myeloma cells, pointing out its pharmocologically prospective selectivity towards the cancer cells over the normal ones. No caspase 3/7 activity was detected in apoptotic KMS12-PE cells treated by complex 6 indicating a different mechanism of apoptosis action from cisplatin. This work demonstrates that simple non-classical platinum(II) complexes represent a new perspective for a monotherapy of hard-to-treat multiple myeloma.

Klíčová slova

BONE-MARROW MICROENVIRONMENT; VITRO ANTITUMOR-ACTIVITY; DNA-BINDING; PLATINUM(II) COMPLEXES; MULTIPLE-MYELOMA; CYTOTOXIC ACTIVITIES; ANTICANCER ACTIVITY; L-METHIONINE; CELL-LINE; CISPLATIN

Autoři

MASARYK, L.; WEISER DROZDKOVÁ, D.; SLOCZYNSKA, K.; MONCOL, J.; MILDE, D.; KRIKAVOVA, R.; POPIOL, J.; PEKALA, E.; ONDRUŠKOVÁ, K.; NEMEC, I.; SMEŠNÝ, K.; ŠTARHA, P.

Vydáno

31. 5. 2023

Nakladatel

Royal Society of Chemistry

Místo

CAMBRIDGE

ISSN

2052-1553

Periodikum

Inorganic Chemistry Frontiers

Ročník

10

Číslo

11

Stát

Spojené království Velké Británie a Severního Irska

Strany od

3307

Strany do

3318

Strany počet

12

URL

https://pubs.rsc.org/en/content/articlelanding/2023/QI/D3QI00327B

Plný text v Digitální knihovně

http://hdl.handle.net/11012/244723

BibTex

@article{BUT184251,
  author="Lukáš {Masaryk} and Denisa {Weiser Drozdková} and Karolina {Sloczynska} and Ján {Moncol} and David {Milde} and Radka {Krikavova} and Justyna {Popiol} and Elzbieta {Pekala} and Katarína {Ondrušková} and Ivan {Nemec} and Kateřina {Smešný} and Pavel {Štarha}",
  title="Anti-myeloma pro-apoptotic Pt(II) diiodido complexes",
  journal="Inorganic Chemistry Frontiers",
  year="2023",
  volume="10",
  number="11",
  pages="3307--3318",
  doi="10.1039/d3qi00327b",
  issn="2052-1553",
  url="https://pubs.rsc.org/en/content/articlelanding/2023/QI/D3QI00327B"
}