Detail publikace

Platinum-based drug-induced depletion of amino acids in the kidneys and liver

MITREVSKA, K. CERNEI, N. MICHÁLKOVÁ, H. MERLOS RODRIGO, M. SIVÁK, L. HEGER, Z. ZÍTKA, O. KOPEL, P. ADAM, V. MILOSAVLJEVIĆ, V.

Originální název

Platinum-based drug-induced depletion of amino acids in the kidneys and liver

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Cisplatin (cis-diamminedichloroplatinum II; CDDP) is a widely used cytostatic agent; however, it tends to promote kidney and liver disease, which are a major signs of drug-induced toxicity. Platinum compounds are often presented as alternative therapeutics and subsequently easily dispersed in the environment as contaminants. Due to the major roles of the liver and kidneys in removing toxic materials from the human body, we performed a comparative study of the amino acid profiles in chicken liver and kidneys before and after the application of CDDP and platinum nanoparticles (PtNPs-10 and PtNPs-40). The treatment of the liver with the selected drugs affected different amino acids; however, Leu and Arg were decreased after all treatments. The treatment of the kidneys with CDDP mostly affected Val; PtNPs-10 decreased Val, Ile and Thr; and PtNPs-40 affected only Pro. In addition, we tested the same drugs on two healthy cell lines, HaCaT and HEK-293, and ultimately explored the amino acid profiles in relation to the tricarboxylic acid cycle (TCA) and methionine cycle, which revealed that in both cell lines, there was a general increase in amino acid concentrations associated with changes in the concentrations of the metabolites of these cycles.

Klíčová slova

amino acids; chicken embryo; platinum nanoparticles; TCA; methionine cycle; toxicity

Autoři

MITREVSKA, K.; CERNEI, N.; MICHÁLKOVÁ, H.; MERLOS RODRIGO, M.; SIVÁK, L.; HEGER, Z.; ZÍTKA, O.; KOPEL, P.; ADAM, V.; MILOSAVLJEVIĆ, V.

Vydáno

21. 9. 2022

ISSN

2234-943X

Periodikum

Frontiers in Oncology

Ročník

12

Číslo

986045

Stát

Švýcarská konfederace

Strany od

1

Strany do

20

Strany počet

20

URL

https://doi.org/10.3389/fonc.2022.986045

BibTex

@article{BUT179946,
  author="MITREVSKA, K. and CERNEI, N. and MICHÁLKOVÁ, H. and MERLOS RODRIGO, M. and SIVÁK, L. and HEGER, Z. and ZÍTKA, O. and KOPEL, P. and ADAM, V. and MILOSAVLJEVIĆ, V.",
  title="Platinum-based drug-induced depletion of amino acids in the kidneys and liver",
  journal="Frontiers in Oncology",
  year="2022",
  volume="12",
  number="986045",
  pages="1--20",
  doi="10.3389/fonc.2022.986045",
  issn="2234-943X",
  url="https://doi.org/10.3389/fonc.2022.986045"
}