Detail publikace

Development of a PCL/gelatin/chitosan/beta-TCP electrospun composite for guided bone regeneration

Masoumeh Ezati, Hamide Safavipour, Behzad Houshmand & Shahab Faghihi

Originální název

Development of a PCL/gelatin/chitosan/beta-TCP electrospun composite for guided bone regeneration

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Many approaches have been developed to regenerate biological substitutes for repairing damaged tissues. Guided bone/tissue regeneration (GBR/GTR) that employs a barrier membrane has received much attention in recent years. Regardless of substantial efforts for treatment of damaged tissue in recent years, an effective therapeutic strategy is still a challenge for tissue engineering researchers. The aim of the current study is to fabricate a GBR membrane consisting of polycaprolactone (PCL)/gelatin/chitosan which is modified with different percentages of beta-tricalcium phosphate (beta-TCP) for improved biocompatibility, mechanical properties, and antibacterial activity. The membranes are examined for their mechanical properties, surface roughness, hydrophilicity, biodegradability and biological response. The mechanical properties, wettability and roughness of the membranes are improved with increases in beta-TCP content. An increase in the elastic modulus of the substrates is obtained as the amount of beta-TCP increases to 5% (145-200 MPa). After 5 h, the number of attached cells is enhanced by 30%, 40% and 50% on membranes having 1%, 3% and 5% beta-TCP, respectively. The cell growth on a membrane with 3% of beta-TCP is also 50% and 20% higher than those without beta-TCP and 5% beta-TCP, respectively. Expression of type I collagen is increased with addition of beta-TCP by 3%, while there is no difference in ALP activity. The results indicated that a composite having (3%) beta-TCP has a potential application for guided bone tissue regeneration.

Klíčová slova

Guided bone regeneration; Electrospinning; beta-Tricalcium phosphate (beta-TCP); Composite membrane

Autoři

Masoumeh Ezati, Hamide Safavipour, Behzad Houshmand & Shahab Faghihi

Vydáno

26. 3. 2018

Nakladatel

SPRINGER HEIDELBERG

Místo

HEIDELBERG

ISSN

2194-0509

Periodikum

Progress in Biomaterials

Ročník

7

Číslo

3

Stát

Spolková republika Německo

Strany od

225

Strany do

237

Strany počet

13

URL

https://link.springer.com/article/10.1007/s40204-018-0098-x#article-info

BibTex

@article{BUT177775,
  author="Masoumeh {Ezati} and Hamide {Safavipour} and Behzad {Houshmand} and Shahab {Faghihi}",
  title="Development of a PCL/gelatin/chitosan/beta-TCP electrospun composite for guided bone regeneration",
  journal="Progress in Biomaterials",
  year="2018",
  volume="7",
  number="3",
  pages="225--237",
  doi="10.1007/s40204-018-0098-x",
  issn="2194-0509",
  url="https://link.springer.com/article/10.1007/s40204-018-0098-x#article-info"
}