Detail publikace

Characteristic Waveforms for Testing of Medical Aerosol Inhalers

PAŠTĚKA, R. FORJAN, M. SANTOS, P.

Originální název

Characteristic Waveforms for Testing of Medical Aerosol Inhalers

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

Respiratory diseases are characterised by high prevalence among the European population. Medical aerosol inhalers are the most commonly used means of drug delivery into the human respiratory system. This paper focuses on characteristic waveforms that can be utilised during aerosol deposition studies to simulate conditions of rapid human inhalation. Additionally, an inhalatory waveform based on clinically recorded spirometry data is introduced. Experimental measurements are performed and simulation results mutually compared using the electro-mechanical lung simulator xPULM™. The inhalatory waveforms are repeatably simulated with high fidelity in regards to the waveform shape with the lowest value of the Goodness of fit 0.89. Additionally, the measured values for all characteristic inhalatory parameters are simulated with low standard deviation σ < 1. The differences between the required and measured waveform shapes are small, ΔPIF < 3 L/min and do not influence the overall inhalatory volume. This opens a possibility of utilising the xPULM for medical aerosol inhalers testing.

Klíčová slova

Inhalatory waveforms, medical aerosol inhalers, electro-mechanical lung simulator, medical device testing

Autoři

PAŠTĚKA, R.; FORJAN, M.; SANTOS, P.

Vydáno

20. 12. 2020

Nakladatel

Springer Science and Business Media Deutschland GmbH

ISBN

978-3-030-64609-7

Kniha

8th European Medical and Biological Engineering Conference

Edice

EMBEC2020

Číslo edice

80

ISSN

1680-0737

Periodikum

IFMBE PROCEEDINGS

Ročník

80

Stát

Švédské království

Strany od

240

Strany do

246

Strany počet

6

URL

https://www.springerprofessional.de/en/characteristic-waveforms-for-testing-of-medical-aerosol-inhalers/18638550

BibTex

@inproceedings{BUT172369,
  author="Richard {Paštěka} and Mathias {Forjan} and Pedro {Santos}",
  title="Characteristic Waveforms for Testing of Medical Aerosol Inhalers",
  booktitle="8th European Medical and Biological Engineering Conference",
  year="2020",
  series="EMBEC2020",
  journal="IFMBE PROCEEDINGS",
  volume="80",
  number="80",
  pages="240--246",
  publisher="Springer Science and Business Media Deutschland GmbH",
  doi="10.1007/978-3-030-64610-3\{_}28",
  isbn="978-3-030-64609-7",
  issn="1680-0737",
  url="https://www.springerprofessional.de/en/characteristic-waveforms-for-testing-of-medical-aerosol-inhalers/18638550"
}