Detail publikace

Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma

PACÍK, D. PLEVOVÁ, M. URBANOVÁ, L. LACKOVÁ, Z. STRMISKA, V. NEČAS, A. HEGER, Z. ADAM, V.

Originální název

Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

The hypothesis that dogs can detect malignant tumours through the identification of specific molecules is nearly 30 years old. To date, several reports have described the successful detection of distinct types of cancer. However, is still a lack of data regarding the specific molecules that can be recognized by a dog's olfactory apparatus. Hence, we performed a study with artificially prepared, well-characterized urinary specimens that were enriched with sarcosine, a widely reported urinary biomarker for prostate cancer (PCa). For the purposes of the study, a German shepherd dog was utilized for analyses of 60 positive and 120 negative samples. Our study provides the first evidence that a sniffer dog specially trained for the olfactory detection of PCa can recognize sarcosine in artificial urine with a performance [sensitivity of 90%, specificity of 95%, and precision of 90% for the highest amount of sarcosine (10 mu mol/ L)] that is comparable to the identification of PCa-diagnosed subjects (sensitivity of 93.5% and specificity of 91.6%). This study casts light on the unrevealed phenomenon of PCa olfactory detection and opens the door for further studies with canine olfactory detection and cancer diagnostics.

Klíčová slova

prostate cancer (PCa); sarcosine; sniffer dog

Autoři

PACÍK, D.; PLEVOVÁ, M.; URBANOVÁ, L.; LACKOVÁ, Z.; STRMISKA, V.; NEČAS, A.; HEGER, Z.; ADAM, V.

Vydáno

1. 12. 2018

Nakladatel

Springer Nature

ISSN

2045-2322

Periodikum

Scientific Reports

Ročník

8

Číslo

4958

Stát

Spojené království Velké Británie a Severního Irska

Strany od

1

Strany do

5

Strany počet

5

URL

http://link.springer.com/article/10.1038/s41598-018-23072-4

Plný text v Digitální knihovně

http://hdl.handle.net/11012/72395

BibTex

@article{BUT147109,
  author="Dalibor {Pacík} and Mariana {Plevová} and Lucie {Urbanová} and Zuzana {Lacková} and Vladislav {Strmiska} and Alois {Nečas} and Zbyněk {Heger} and Vojtěch {Adam}",
  title="Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma",
  journal="Scientific Reports",
  year="2018",
  volume="8",
  number="4958",
  pages="1--5",
  doi="10.1038/s41598-018-23072-4",
  issn="2045-2322",
  url="http://link.springer.com/article/10.1038/s41598-018-23072-4"
}