Detail publikace

G-Quadruplexes as Sensing Probes

RUTTKAY-NEDECKÝ, B. KUDR, J. NEJDL, L. MAŠKOVÁ, D. KIZEK, R. ADAM, V.

Originální název

G-Quadruplexes as Sensing Probes

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. G-quadruplexes act as ligands for metal ions and aptamers for various molecules. Interestingly, the G-quadruplexes form a complex with anionic porphyrin hemin and exhibit peroxidase-like activity. This review focuses on overview of sensing techniques based on G-quadruplex complexes with anionic porphyrins for detection of various analytes, including metal ions such as K+, Ca2+, Ag+, Hg2+, Cu2+, Pb2+, Sr2+, organic molecules, nucleic acids, and proteins. Principles of G-quadruplex-based detection methods involve DNA conformational change caused by the presence of analyte which leads to a decrease or an increase in peroxidase activity, fluorescence, or electrochemical signal of the used probe. The advantages of various detection techniques are also discussed.

Klíčová slova

G-quadruplex; DNAzyme; hemin

Autoři

RUTTKAY-NEDECKÝ, B.; KUDR, J.; NEJDL, L.; MAŠKOVÁ, D.; KIZEK, R.; ADAM, V.

Vydáno

1. 12. 2013

Nakladatel

MDPI

ISSN

1420-3049

Periodikum

MOLECULES

Ročník

18

Číslo

12

Stát

Švýcarská konfederace

Strany od

14760

Strany do

14779

Strany počet

20

URL

https://www.mdpi.com/1420-3049/18/12/14760

Plný text v Digitální knihovně

http://hdl.handle.net/11012/137244

BibTex

@article{BUT145126,
  author="Branislav {Ruttkay-Nedecký} and Jiří {Kudr} and Lukáš {Nejdl} and Darina {Mašková} and René {Kizek} and Vojtěch {Adam}",
  title="G-Quadruplexes as Sensing Probes",
  journal="MOLECULES",
  year="2013",
  volume="18",
  number="12",
  pages="14760--14779",
  doi="10.3390/molecules181214760",
  issn="1420-3049",
  url="https://www.mdpi.com/1420-3049/18/12/14760"
}