Detail publikace

Metallothionein as a Scavenger of Free Radicals - New Cardioprotective Therapeutic Agent or Initiator of Tumor Chemoresistance?

HEGER, Z. MERLOS RODRIGO, M. KŘÍŽKOVÁ, S. RUTTKAY-NEDECKÝ, B. ZALEWSKA, M. PLANELLS DEL POZO, E. PELFRENE, A. POURRUT, B. STIBOROVÁ, M. ECKSCHLAGER, T. EMRI, G. KIZEK, R. ADAM, V.

Originální název

Metallothionein as a Scavenger of Free Radicals - New Cardioprotective Therapeutic Agent or Initiator of Tumor Chemoresistance?

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Cardiotoxicity is a serious complication of anticancer therapy by anthracycline antibiotics. Except for intercalation into DNA/RNA structure, inhibition of DNA-topoisomerase and histone eviction from chromatin, the main mechanism of their action is iron-mediated formation of various forms of free radicals, which leads to irreversible damage to cancer cells. The most serious adverse effect of anthracyclines is, thus, cardiomyopathy leading to congestive heart failure, which is caused by the same mechanisms. Here, we briefly summarize the basic types of free radicals formed by anthracyclines and the main processes how to scavenge them. From these, the main attention is paid to metallothioneins. These low-molecular cysteine-rich proteins are introduced and their functions and properties are reviewed. Further, their role in detoxification of metals and drugs is discussed. Based on these beneficial roles, their use as a new therapeutic agent against oxidative stress and for cardioprotection is critically evaluated with respect to their ability to increase chemoresistance against some types of commonly used cytostatics.

Klíčová slova

Anthracyclines; cardioprotection; cellular oxidative stress; chemoresistance; doxorubicin; free radicals; metal-lothionein

Autoři

HEGER, Z.; MERLOS RODRIGO, M.; KŘÍŽKOVÁ, S.; RUTTKAY-NEDECKÝ, B.; ZALEWSKA, M.; PLANELLS DEL POZO, E.; PELFRENE, A.; POURRUT, B.; STIBOROVÁ, M.; ECKSCHLAGER, T.; EMRI, G.; KIZEK, R.; ADAM, V.

Vydáno

1. 1. 2016

ISSN

1389-4501

Periodikum

CURRENT DRUG TARGETS

Ročník

17

Číslo

12

Stát

Stát Spojené arabské emiráty

Strany od

1438

Strany do

1451

Strany počet

14

BibTex

@article{BUT143010,
  author="Zbyněk {Heger} and Miguel Ángel {Merlos Rodrigo} and Soňa {Křížková} and Branislav {Ruttkay-Nedecký} and Marta Barbara {Zalewska} and Ellena {Planells del Pozo} and Aurelie {Pelfrene} and Bertrand {Pourrut} and Marie {Stiborová} and Tomáš {Eckschlager} and Gabriela {Emri} and René {Kizek} and Vojtěch {Adam}",
  title="Metallothionein as a Scavenger of Free Radicals - New Cardioprotective Therapeutic Agent or Initiator of Tumor Chemoresistance?",
  journal="CURRENT DRUG TARGETS",
  year="2016",
  volume="17",
  number="12",
  pages="1438--1451",
  doi="10.2174/1389450116666151001113304",
  issn="1389-4501"
}