Detail publikace

Colloid Properties of Phospholipids Aggregates

Originální název

Colloid Properties of Phospholipids Aggregates

Anglický název

Colloid Properties of Phospholipids Aggregates

Jazyk

en

Originální abstrakt

Microbubbles are used as contrast agents in combination with ultrasound mostly for cardiovascular imaging or the assessment of perfusion of various organs and tumors. The aim of our study was to evaluate ability of solubilization and formation process of microbubble SonoVue phospholipid liposomes and surfactant micelles as basis for development of new contrast agent for drug delivery applications. Ability of solubilization was study using the UV-VIS spectroscopy and solubilizing capacity was determined using hydrophobic solutes because of obtaining a model system of solubilized drugs or vitamins which are also hydrophobic. Microbubble and liposomes formation process was investigated using surface tension measurements, specifically maximum bubble pressure method.

Anglický abstrakt

Microbubbles are used as contrast agents in combination with ultrasound mostly for cardiovascular imaging or the assessment of perfusion of various organs and tumors. The aim of our study was to evaluate ability of solubilization and formation process of microbubble SonoVue phospholipid liposomes and surfactant micelles as basis for development of new contrast agent for drug delivery applications. Ability of solubilization was study using the UV-VIS spectroscopy and solubilizing capacity was determined using hydrophobic solutes because of obtaining a model system of solubilized drugs or vitamins which are also hydrophobic. Microbubble and liposomes formation process was investigated using surface tension measurements, specifically maximum bubble pressure method.

BibTex


@misc{BUT110489,
  author="Tereza {Pilgrová} and Filip {Mravec} and Zdeňka {Gregorová} and Marek {Orban} and Miloslav {Pekař}",
  title="Colloid Properties of Phospholipids Aggregates",
  annote="Microbubbles are used as contrast agents in combination with ultrasound mostly for cardiovascular imaging or the assessment of perfusion of various organs and tumors. The aim of our study was to evaluate ability of solubilization and formation process of microbubble SonoVue phospholipid liposomes and surfactant micelles as basis for development of new contrast agent for drug delivery applications. Ability of solubilization was study using the UV-VIS spectroscopy and solubilizing capacity was determined using hydrophobic solutes because of obtaining a model system of solubilized drugs or vitamins which are also hydrophobic. Microbubble and liposomes formation process was investigated using surface tension measurements, specifically maximum bubble pressure method.",
  chapter="110489",
  year="2014",
  month="september",
  pages="116--117",
  type="abstract"
}