Detail publikace

The magnitude and course of exercise-induced stroke volume changes determine the exercise tolerance in heart transplant recipients with heart failure and normal ejection fraction

MELUZÍN, J. HUDE, P. LEINVEBER, P. JURÁK, P. SOUKUP, L. VIŠČOR, I. ŠPINAROVÁ, L. ŠTĚPÁNOVÁ, R. PODROUŽKOVÁ, H. VONDRA, V. LANGER, P. NĚMEC, P.

Originální název

The magnitude and course of exercise-induced stroke volume changes determine the exercise tolerance in heart transplant recipients with heart failure and normal ejection fraction

Český název

The magnitude and course of exercise-induced stroke volume changes determine the exercise tolerance in heart transplant recipients with heart failure and normal ejection fraction

Anglický název

The magnitude and course of exercise-induced stroke volume changes determine the exercise tolerance in heart transplant recipients with heart failure and normal ejection fraction

Typ

článek v časopise

Jazyk

en

Originální abstrakt

Objectives: There is a large variability of exercise-induced stroke volume behavior in healthy subjects. We sought to assess the course of exercise-induced changes in stroke volume index (SVI) and other functional parameters in post-heart transplant patients with heart failure and normal left ventricular ejection fraction (HFNEF). Methods: Left ventricular function and systemic hemodynamics were assessed at 40 s intervals during the exercise in 39 patients using simultaneous right heart catheterization, bioimpedance, and echocardiography. Results: Twenty-six patients had exercise tolerance lower than 4.0 METs (Group A), while 13 patients exhibited severely limited exercise tolerance < 4 METs (Group B). Maximal SVI (maxSVI) achieved at any time during the exercise exceeded SVI at peak exercise (peakSVI) in 26 patients (67%). Both maxSVI and maxSVI (maxSVI minus SVI at rest) were significantly higher in Group A compared to Group B patients (59 ml/m2 vs 41 ml/m2, p < 0.01, and 21 ml/m2 vs 6 ml/m2 peakSVI, maxSVI, peakSVI, maxSVI and other variables evaluated, only maxSVI was independently associated with exercise tolerance. Conclusion: When assessing exercise-induced SVI changes in HFNEF patients, SVI should be followed during the course of exercise and maximal SVI change from rest should always be determined.

Český abstrakt

Objectives: There is a large variability of exercise-induced stroke volume behavior in healthy subjects. We sought to assess the course of exercise-induced changes in stroke volume index (SVI) and other functional parameters in post-heart transplant patients with heart failure and normal left ventricular ejection fraction (HFNEF). Methods: Left ventricular function and systemic hemodynamics were assessed at 40 s intervals during the exercise in 39 patients using simultaneous right heart catheterization, bioimpedance, and echocardiography. Results: Twenty-six patients had exercise tolerance lower than 4.0 METs (Group A), while 13 patients exhibited severely limited exercise tolerance < 4 METs (Group B). Maximal SVI (maxSVI) achieved at any time during the exercise exceeded SVI at peak exercise (peakSVI) in 26 patients (67%). Both maxSVI and maxSVI (maxSVI minus SVI at rest) were significantly higher in Group A compared to Group B patients (59 ml/m2 vs 41 ml/m2, p < 0.01, and 21 ml/m2 vs 6 ml/m2 peakSVI, maxSVI, peakSVI, maxSVI and other variables evaluated, only maxSVI was independently associated with exercise tolerance. Conclusion: When assessing exercise-induced SVI changes in HFNEF patients, SVI should be followed during the course of exercise and maximal SVI change from rest should always be determined.

Anglický abstrakt

Objectives: There is a large variability of exercise-induced stroke volume behavior in healthy subjects. We sought to assess the course of exercise-induced changes in stroke volume index (SVI) and other functional parameters in post-heart transplant patients with heart failure and normal left ventricular ejection fraction (HFNEF). Methods: Left ventricular function and systemic hemodynamics were assessed at 40 s intervals during the exercise in 39 patients using simultaneous right heart catheterization, bioimpedance, and echocardiography. Results: Twenty-six patients had exercise tolerance lower than 4.0 METs (Group A), while 13 patients exhibited severely limited exercise tolerance < 4 METs (Group B). Maximal SVI (maxSVI) achieved at any time during the exercise exceeded SVI at peak exercise (peakSVI) in 26 patients (67%). Both maxSVI and maxSVI (maxSVI minus SVI at rest) were significantly higher in Group A compared to Group B patients (59 ml/m2 vs 41 ml/m2, p < 0.01, and 21 ml/m2 vs 6 ml/m2 peakSVI, maxSVI, peakSVI, maxSVI and other variables evaluated, only maxSVI was independently associated with exercise tolerance. Conclusion: When assessing exercise-induced SVI changes in HFNEF patients, SVI should be followed during the course of exercise and maximal SVI change from rest should always be determined.

Klíčová slova

Heart failure; Stroke volume index; Exercise tolerance; Bioimpedance.

Vydáno

13.02.2014

Nakladatel

Cardiology Academic Press

Strany od

674

Strany do

687

Strany počet

14

BibTex


@article{BUT105762,
  author="Jaroslav {Meluzín} and Petr {Hude} and Pavel {Leinveber} and Pavel {Jurák} and Ladislav {Soukup} and Ivo {Viščor} and Lenka {Špinarová} and Radka {Štěpánová} and Helena {Podroužková} and Vlastimil {Vondra} and Peter {Langer} and Petr {Němec}",
  title="The magnitude and course of exercise-induced stroke volume changes determine the exercise tolerance in heart transplant recipients with heart failure and normal ejection fraction",
  annote="Objectives: There is a large variability of exercise-induced stroke volume behavior in healthy subjects. We sought to assess the course of exercise-induced changes in stroke volume index (SVI) and other functional parameters in post-heart transplant patients with heart failure and normal left ventricular ejection fraction (HFNEF). Methods: Left ventricular function and systemic hemodynamics were assessed at 40 s intervals during the exercise in 39 patients using simultaneous right heart catheterization, bioimpedance, and echocardiography. Results: Twenty-six patients had exercise tolerance lower than 4.0 METs (Group A), while 13 patients exhibited severely limited exercise tolerance < 4 METs (Group B). Maximal SVI (maxSVI) achieved at any time during the exercise exceeded SVI at peak exercise (peakSVI) in 26 patients (67%). Both maxSVI and maxSVI (maxSVI minus SVI at rest) were significantly higher in Group A compared to Group B patients (59 ml/m2 vs 41 ml/m2, p < 0.01, and 21 ml/m2  vs 6 ml/m2 peakSVI, maxSVI, peakSVI, maxSVI and other variables evaluated, only maxSVI was 
independently associated with exercise tolerance. Conclusion: When assessing exercise-induced SVI changes in HFNEF patients, SVI should be followed during the course of exercise and maximal SVI change from rest should always be determined.",
  address="Cardiology Academic Press",
  chapter="105762",
  institution="Cardiology Academic Press",
  number="1",
  volume="20",
  year="2014",
  month="february",
  pages="674--687",
  publisher="Cardiology Academic Press",
  type="journal article"
}