Detail publikace

The magnitude and course of exercise-induced stroke volume changes determine the exercise tolerance in heart transplant recipients with heart failure and normal ejection fraction

Originální název

The magnitude and course of exercise-induced stroke volume changes determine the exercise tolerance in heart transplant recipients with heart failure and normal ejection fraction

Anglický název

The magnitude and course of exercise-induced stroke volume changes determine the exercise tolerance in heart transplant recipients with heart failure and normal ejection fraction

Jazyk

en

Originální abstrakt

Objectives: There is a large variability of exercise-induced stroke volume behavior in healthy subjects. We sought to assess the course of exercise-induced changes in stroke volume index (SVI) and other functional parameters in post-heart transplant patients with heart failure and normal left ventricular ejection fraction (HFNEF). Methods: Left ventricular function and systemic hemodynamics were assessed at 40 s intervals during the exercise in 39 patients using simultaneous right heart catheterization, bioimpedance, and echocardiography. Results: Twenty-six patients had exercise tolerance lower than 4.0 METs (Group A), while 13 patients exhibited severely limited exercise tolerance < 4 METs (Group B). Maximal SVI (maxSVI) achieved at any time during the exercise exceeded SVI at peak exercise (peakSVI) in 26 patients (67%). Both maxSVI and maxSVI (maxSVI minus SVI at rest) were significantly higher in Group A compared to Group B patients (59 ml/m2 vs 41 ml/m2, p < 0.01, and 21 ml/m2 vs 6 ml/m2 peakSVI, maxSVI, peakSVI, maxSVI and other variables evaluated, only maxSVI was independently associated with exercise tolerance. Conclusion: When assessing exercise-induced SVI changes in HFNEF patients, SVI should be followed during the course of exercise and maximal SVI change from rest should always be determined.

Anglický abstrakt

Objectives: There is a large variability of exercise-induced stroke volume behavior in healthy subjects. We sought to assess the course of exercise-induced changes in stroke volume index (SVI) and other functional parameters in post-heart transplant patients with heart failure and normal left ventricular ejection fraction (HFNEF). Methods: Left ventricular function and systemic hemodynamics were assessed at 40 s intervals during the exercise in 39 patients using simultaneous right heart catheterization, bioimpedance, and echocardiography. Results: Twenty-six patients had exercise tolerance lower than 4.0 METs (Group A), while 13 patients exhibited severely limited exercise tolerance < 4 METs (Group B). Maximal SVI (maxSVI) achieved at any time during the exercise exceeded SVI at peak exercise (peakSVI) in 26 patients (67%). Both maxSVI and maxSVI (maxSVI minus SVI at rest) were significantly higher in Group A compared to Group B patients (59 ml/m2 vs 41 ml/m2, p < 0.01, and 21 ml/m2 vs 6 ml/m2 peakSVI, maxSVI, peakSVI, maxSVI and other variables evaluated, only maxSVI was independently associated with exercise tolerance. Conclusion: When assessing exercise-induced SVI changes in HFNEF patients, SVI should be followed during the course of exercise and maximal SVI change from rest should always be determined.

Dokumenty

BibTex


@article{BUT105762,
  author="Jaroslav {Meluzín} and Petr {Hude} and Pavel {Leinveber} and Pavel {Jurák} and Ladislav {Soukup} and Ivo {Viščor} and Lenka {Špinarová} and Radka {Štěpánová} and Helena {Podroužková} and Vlastimil {Vondra} and Peter {Langer} and Petr {Němec}",
  title="The magnitude and course of exercise-induced stroke volume changes determine the exercise tolerance in heart transplant recipients with heart failure and normal ejection fraction",
  annote="Objectives: There is a large variability of exercise-induced stroke volume behavior in healthy subjects. We sought to assess the course of exercise-induced changes in stroke volume index (SVI) and other functional parameters in post-heart transplant patients with heart failure and normal left ventricular ejection fraction (HFNEF). Methods: Left ventricular function and systemic hemodynamics were assessed at 40 s intervals during the exercise in 39 patients using simultaneous right heart catheterization, bioimpedance, and echocardiography. Results: Twenty-six patients had exercise tolerance lower than 4.0 METs (Group A), while 13 patients exhibited severely limited exercise tolerance < 4 METs (Group B). Maximal SVI (maxSVI) achieved at any time during the exercise exceeded SVI at peak exercise (peakSVI) in 26 patients (67%). Both maxSVI and maxSVI (maxSVI minus SVI at rest) were significantly higher in Group A compared to Group B patients (59 ml/m2 vs 41 ml/m2, p < 0.01, and 21 ml/m2  vs 6 ml/m2 peakSVI, maxSVI, peakSVI, maxSVI and other variables evaluated, only maxSVI was 
independently associated with exercise tolerance. Conclusion: When assessing exercise-induced SVI changes in HFNEF patients, SVI should be followed during the course of exercise and maximal SVI change from rest should always be determined.",
  address="Cardiology Academic Press",
  chapter="105762",
  institution="Cardiology Academic Press",
  number="1",
  volume="20",
  year="2014",
  month="february",
  pages="674--687",
  publisher="Cardiology Academic Press",
  type="journal article - other"
}