Detail projektu

Low temperature 3D printed bioresorbable hydrogels as carriers of pro-healing protein for tissue regeneration

Období řešení: 01.02.2021 — 31.01.2022

Zdroje financování

Evropská unie - Interní grantová soutěž

- plně financující (2021-02-01 - 2022-01-31)

O projektu

Extrusion based 3D printing records growth in tissue engineering to produce pharmaceuticals and medical implants. In this project, bioresorbable hydrogel based on lactic and glycolic acid (PLGA-PEG-PLGA) modified with double bonds suitable for blue light crosslinking (synthesized and patented by CEITEC) will be firstly applied for the low temperature extrusion 3D printing. Prior to 3D printing, hydrogels will be enriched with pro-healing protein (FGF2-STAB). Stability of printed hydrogel carriers at physiological conditions, their mechanical properties and protein release will be evaluated.

Označení

CEITEC-K-21-6889

Originální jazyk

čeština

Řešitelé

Lysáková Klára, Ing. - hlavní řešitel
Hlináková Kristýna, Ing. - spoluřešitel

Útvary

Pokročilé biomateriály
- spolupříjemce (01.02.2021 - 31.01.2022)
Středoevropský technologický institut VUT
- příjemce (01.02.2021 - 31.01.2022)
Středoevropský technologický institut
- interní (01.02.2021 - 31.01.2022)

Výsledky

LYSÁKOVÁ, K.; HLINÁKOVÁ, K.; BRTNÍKOVÁ, J.; VOJTOVÁ, L. „Smart“ biodegradable hydrogel as carrier for pro-healing proteins applicable in regenerative medicine: synthesis, characterization and controlled release. eCM Periodical. eCM Meeting Abstracts, 2021. p. 25-25. ISSN: 2522-235X.
Detail

LYSÁKOVÁ, K.; HLINÁKOVÁ, K.; KŘIVÁNKOVÁ, N.; VOJTOVÁ, L. Pro-healing protein release from 3D-printed „smart“ hydrogel carriers applicable in regenerative medicine. THE TWENTY-SECOND ANNUAL CONFERENCE YUCOMAT 2021 Program and Book of Abstracts. Belgrade: Materials Research Society of Serbia, 2021. p. 82-82. ISBN: 978-86-919111-6-4.
Detail

KADLECOVÁ, Z.; LYSÁKOVÁ, K.; VOJTOVÁ, L. 3D printed Calcium Phosphate Cements enriched with liposome-encapsulated antibacterial enzymes for bone infection treatment. Czech Chemical Society Symposium Series. Czech Chemical Society, 2023. p. 88-88. ISSN: 2336-7210.
Detail

LYSÁKOVÁ, K.; HLINÁKOVÁ, K.; KUTÁLKOVÁ, K.; CHALOUPKOVA, R.; ŽÍDEK, J.; BRTNÍKOVÁ, J.; VOJTOVÁ, L. A novel approach in control release monitoring of protein-based bioactive substances from injectable PLGA-PEG-PLGA hydrogel. EXPRESS POLYM LETT, 2022, vol. 16, no. 8, p. 798-811. ISSN: 1788-618X.
Detail

HLINÁKOVÁ, K.; LYSÁKOVÁ, K.; KŘIVÁNKOVÁ, N.; VOJTOVÁ, L. Viscoelastic properties of resorbable PLGA-PEG-PLGA based bioinks for additive manufacturing technology in regenerative medicine. THE TWENTY-SECOND ANNUAL CONFERENCE YUCOMAT 2021, Program and the Book of Abstract. Belgrade, Serbia: Material Research Society of Serbia, 2021. p. 83-83. ISBN: 978-86-919111-6-4.
Detail

Odpovědnost: Lysáková Klára, Ing.