Detail publikace

Impact Of Parapapillary Autofluorescence In Glaucoma: Clinical Aspects

LAEMMER, R. KOLÁŘ, R. JAN, J. MARDIN, C.

Originální název

Impact Of Parapapillary Autofluorescence In Glaucoma: Clinical Aspects

Anglický název

Impact Of Parapapillary Autofluorescence In Glaucoma: Clinical Aspects

Typ

článek v časopise - ostatní, Jost

Jazyk

čeština

Originální abstrakt

Parapapillary atrophy is an important clinical sign associated with progressive optic disc damage and visual field loss in patients with glaucoma. Histologic and spectroscopic results revealed an accumulation of lipofuscin as the dominant fundus fluorophore localized in the lysosomes of the retinal pigmentepithelium in the parapapillary atrophic zone. We investigated morphologic characteristics of parapapillary autofluorescence in patients with different entities and stages of glaucoma compared to healthy controls using Scanning Laser Ophthalmoscopy. Autofluorescence was measured with HRA standard software and compared to a new semiautomatic approach. Both, area and mean distance of the autofluorescence regions from the optic disc border were well associated with increasing glaucomatous damage. Changes were more pronounced for early stages. Semiautomatic segmentation improved interobserver variability.

Anglický abstrakt

Parapapillary atrophy is an important clinical sign associated with progressive optic disc damage and visual field loss in patients with glaucoma. Histologic and spectroscopic results revealed an accumulation of lipofuscin as the dominant fundus fluorophore localized in the lysosomes of the retinal pigmentepithelium in the parapapillary atrophic zone. We investigated morphologic characteristics of parapapillary autofluorescence in patients with different entities and stages of glaucoma compared to healthy controls using Scanning Laser Ophthalmoscopy. Autofluorescence was measured with HRA standard software and compared to a new semiautomatic approach. Both, area and mean distance of the autofluorescence regions from the optic disc border were well associated with increasing glaucomatous damage. Changes were more pronounced for early stages. Semiautomatic segmentation improved interobserver variability.

Klíčová slova

glaucoma, retinal imaging, autofluorescence

Klíčová slova v angličtině

glaucoma, retinal imaging, autofluorescence

Autoři

LAEMMER, R.; KOLÁŘ, R.; JAN, J.; MARDIN, C.

Rok RIV

2008

Vydáno

27. 6. 2008

ISSN

1211-412X

Periodikum

Analysis of Biomedical Signals and Images

Ročník

19

Číslo

1

Stát

Česká republika

Strany od

1

Strany do

4

Strany počet

4

URL

https://ipac.svkkl.cz/arl-kl/cs/detail-kl_us_cat-1441077-Analysis-of-biomedical-signals-and-images/

BibTex

@article{BUT49681,
  author="Radim {Kolář} and Robert {Laemmer} and Jiří {Jan} and Christian Y {Mardin}",
  title="Impact Of Parapapillary Autofluorescence In Glaucoma: Clinical Aspects",
  journal="Analysis of Biomedical Signals and Images",
  year="2008",
  volume="19",
  number="1",
  pages="1--4",
  issn="1211-412X",
  url="https://ipac.svkkl.cz/arl-kl/cs/detail-kl_us_cat-1441077-Analysis-of-biomedical-signals-and-images/"
}