Detail publikace

A Comparative Tool for the Validity of Rate Kinetics in Ion Channels by Onsager Reciprocity Theorem

OZER, M. PROVAZNÍK, I.

Originální název

A Comparative Tool for the Validity of Rate Kinetics in Ion Channels by Onsager Reciprocity Theorem

Typ

článek v časopise - ostatní, Jost

Jazyk

angličtina

Originální abstrakt

The precise form of the rate constant functions of ion channels is very crucial for reproducing the electrophysiological behavior. Therefore, how well they account for experimental data plays an important role in the behavior of the model. In this study, we derive kinetic coefficients of activation and inactivation gates in ion channels by Onsager reciprocity theorem for an ensemble of gating particles, and propose that the obtained kinetic coefficients can be used as a comparative tool for the empirical validity of fitted rate constant functions to experimental data. We also illustrate its applicability based on the activation and inactivation kinetics of T-type calcium channel in thalamic relay neurons. We show that the shape of the steady-state curve by itself seems to be a poor indicator of the functional form of the rate functions, but the time constant curves reflect considerable variation depending on the particular form of the rate functions, and that the kinetic coefficients related to the time constants provide a powerful tool to determine the empirical validity of the fitted rate constants.

Klíčová slova

Kinetic coefficient; Ion channel; Rate kinetics; Onsager reciprocity theorem

Autoři

OZER, M.; PROVAZNÍK, I.

Rok RIV

2004

Vydáno

1. 10. 2004

Nakladatel

Elsevier

ISSN

0022-5193

Periodikum

Journal of Theoretical Biology

Ročník

233

Číslo

2

Stát

Spojené státy americké

Strany od

237

Strany do

243

Strany počet

7

BibTex

@article{BUT42154,
  author="Mahmut {Ozer} and Valentine {Provazník}",
  title="A Comparative Tool for the Validity of Rate Kinetics in Ion Channels by Onsager Reciprocity Theorem",
  journal="Journal of Theoretical Biology",
  year="2004",
  volume="233",
  number="2",
  pages="7",
  issn="0022-5193"
}