Detail publikace

A novel ruthenium based coordination compound against pathogenic bacteria

SUR, V. MAZUMDAR, A. KOPEL, P. MUKHERJEE, S. VÍTEK, P. MICHÁLKOVÁ, H. VACULOVIČOVÁ, M. MOULICK, A.

Originální název

A novel ruthenium based coordination compound against pathogenic bacteria

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

The current epidemic of antibiotic-resistant infections urges to develop alternatives to less-effective antibiotics. To assess anti-bacterial potential, a novel coordinate compound (RU-S4) was synthesized using ruthenium-Schiff base-benzimidazole ligand, where ruthenium chloride was used as the central atom. RU-S4 was characterized by scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), and Raman spectroscopy. Antibacterial effect of RU-S4 was studied against Staphylococcus aureus (NCTC 8511), vancomycin-resistant Staphylococcus aureus (VRSA) (CCM 1767), methicillin-resistant Staphylococcus aureus (MRSA) (ST239: SCCmecIIIA), and hospital isolate Staphylococcus epidermidis. The antibacterial activity of RU-S4 was checked by growth curve analysis and the outcome was supported by optical microscopy imaging and fluorescence LIVE/DEAD cell imaging. In vivo (balb/c mice) infection model prepared with VRSA (CCM 1767) and treated with RU-S4. In our experimental conditions, all infected mice were cured. The interaction of coordination compound with bacterial cells were further confirmed by cryo-scanning electron microscope (Cryo-SEM). RU-S4 was completely non-toxic against mammalian cells and in mice and subsequently treated with synthesized RU-S4.

Klíčová slova

coordination compound; antimicrobial compound; ruthenium; benzimidazole; SEM; EDS

Autoři

SUR, V.; MAZUMDAR, A.; KOPEL, P.; MUKHERJEE, S.; VÍTEK, P.; MICHÁLKOVÁ, H.; VACULOVIČOVÁ, M.; MOULICK, A.

Vydáno

10. 4. 2020

Nakladatel

MDPI

ISSN

1422-0067

Periodikum

International Journal of Molecular Sciences

Ročník

21

Číslo

7

Stát

Švýcarská konfederace

Strany od

1

Strany do

18

Strany počet

18

URL

https://www.mdpi.com/1422-0067/21/7/2656

Plný text v Digitální knihovně

http://hdl.handle.net/11012/189392

BibTex

@article{BUT164290,
  author="Vishma Pratap {Sur} and Aninda {Mazumdar} and Pavel {Kopel} and S. {Mukherjee} and Petr {Vítek} and Hana {Michálková} and Markéta {Vaculovičová} and Amitava {Moulick}",
  title="A novel ruthenium based coordination compound against pathogenic bacteria",
  journal="International Journal of Molecular Sciences",
  year="2020",
  volume="21",
  number="7",
  pages="1--18",
  doi="10.3390/ijms21072656",
  issn="1422-0067",
  url="https://www.mdpi.com/1422-0067/21/7/2656"
}