Detail publikace

Bioeconomic polyhydroxyalkanoate (PHA) manufacturing, and factors boosting PHA biosynthesis

Originální název

Bioeconomic polyhydroxyalkanoate (PHA) manufacturing, and factors boosting PHA biosynthesis

Anglický název

Bioeconomic polyhydroxyalkanoate (PHA) manufacturing, and factors boosting PHA biosynthesis

Jazyk

en

Originální abstrakt

Several steps of the process chain to biosynthesize microbialpolyhydroxyalkanoate (PHA) biopolyesters need to be consideredin order to make these auspicious biopolyesters quantitatively andqualitatively competitive on the global plastic market. Selection,adaptation and genetic modification of microbial strains, feedstocksupply, bioreactor design and process regime, and product recov-ery require optimization. Especially the application of robust, fastgrowing and highly productive microbial species for PHA pro-duction using inexpensive carbon-rich feedstocks has become afrequently used strategy towards economically feasible PHA pro-duction. During biosynthesis, exogenous stress factors triggeringPHA accumulation in microbial biomass play a still underestimatedrole. As recently revealed, presence of PHA helps cells to mitigatethe harmful effects of diverse stress factors like osmotic imbal-ance, oxidative challenge or UV-radiation; biotechnologically, onecan deliberately expose bacterial cells to such stress conditions toboost intracellular PHA biosynthesis. From the engineering per-spective, new bioreactors and continuous operation mode increasePHA productivity and customize PHA’s properties. Together withthe application of sustainable techniques to recover PHA frommicrobial biomass, such as using recyclable and eco-friendly sol-vents under extreme extraction conditions, PHA manufacturingcan be configured as entirely green and sustainable bioeconomictechnology.

Anglický abstrakt

Several steps of the process chain to biosynthesize microbialpolyhydroxyalkanoate (PHA) biopolyesters need to be consideredin order to make these auspicious biopolyesters quantitatively andqualitatively competitive on the global plastic market. Selection,adaptation and genetic modification of microbial strains, feedstocksupply, bioreactor design and process regime, and product recov-ery require optimization. Especially the application of robust, fastgrowing and highly productive microbial species for PHA pro-duction using inexpensive carbon-rich feedstocks has become afrequently used strategy towards economically feasible PHA pro-duction. During biosynthesis, exogenous stress factors triggeringPHA accumulation in microbial biomass play a still underestimatedrole. As recently revealed, presence of PHA helps cells to mitigatethe harmful effects of diverse stress factors like osmotic imbal-ance, oxidative challenge or UV-radiation; biotechnologically, onecan deliberately expose bacterial cells to such stress conditions toboost intracellular PHA biosynthesis. From the engineering per-spective, new bioreactors and continuous operation mode increasePHA productivity and customize PHA’s properties. Together withthe application of sustainable techniques to recover PHA frommicrobial biomass, such as using recyclable and eco-friendly sol-vents under extreme extraction conditions, PHA manufacturingcan be configured as entirely green and sustainable bioeconomictechnology.

Dokumenty

BibTex


@misc{BUT163454,
  author="Stanislav {Obruča}",
  title="Bioeconomic polyhydroxyalkanoate (PHA) manufacturing, and factors boosting PHA biosynthesis",
  annote="Several steps of the process chain to biosynthesize microbialpolyhydroxyalkanoate (PHA) biopolyesters need to be consideredin order to make these auspicious biopolyesters quantitatively andqualitatively competitive on the global plastic market. Selection,adaptation and genetic modification of microbial strains, feedstocksupply, bioreactor design and process regime, and product recov-ery require optimization. Especially the application of robust, fastgrowing and highly productive microbial species for PHA pro-duction using inexpensive carbon-rich feedstocks has become afrequently used strategy towards economically feasible PHA pro-duction. During biosynthesis, exogenous stress factors triggeringPHA accumulation in microbial biomass play a still underestimatedrole. As recently revealed, presence of PHA helps cells to mitigatethe harmful effects of diverse stress factors like osmotic imbal-ance, oxidative challenge or UV-radiation; biotechnologically, onecan deliberately expose bacterial cells to such stress conditions toboost intracellular PHA biosynthesis. From the engineering per-spective, new bioreactors and continuous operation mode increasePHA productivity and customize PHA’s properties. Together withthe application of sustainable techniques to recover PHA frommicrobial biomass, such as using recyclable and eco-friendly sol-vents under extreme extraction conditions, PHA manufacturingcan be configured as entirely green and sustainable bioeconomictechnology.",
  address="Elsevier",
  chapter="163454",
  doi="10.1016/j.jbiotec.2019.05.028",
  howpublished="online",
  institution="Elsevier",
  year="2019",
  month="november",
  pages="4--4",
  publisher="Elsevier",
  type="abstract"
}