Detail publikace

Measurement of orientation of fibres in a simplified replica of human trachea under steady conditions

Originální název

Measurement of orientation of fibres in a simplified replica of human trachea under steady conditions

Anglický název

Measurement of orientation of fibres in a simplified replica of human trachea under steady conditions

Jazyk

en

Originální abstrakt

Although inhalable fibres are mostly regarded as dangerous and harmful because they are mostly associated with asbestos, several authors have recommended the application of tubular or fibrous particles for drug delivery. Chan and Gonda (1989) were among the first who ventured to enter the unexplored realm of pharmaceutically usable fibres. They prepared fibres from cromoglycic acid which has low solubility in water and therefore should not experience significant hygroscopic growth in the airways. Johnson et al. (2000) suggested packing tubular shell particles with an Active Pharmaceutical Ingredient (API) to maximise the per particle dose while targeting distal regions of lungs. Martin and Finlay (2008) have demonstrated the applicability of magnetic field targeting of magnetite-loaded fibres for efficient delivery to specified locations in lungs and encouraged other researchers to develop formulations with fibrous aerosol incorporating chemotherapeutic agents for the treatment of lung cancer.

Anglický abstrakt

Although inhalable fibres are mostly regarded as dangerous and harmful because they are mostly associated with asbestos, several authors have recommended the application of tubular or fibrous particles for drug delivery. Chan and Gonda (1989) were among the first who ventured to enter the unexplored realm of pharmaceutically usable fibres. They prepared fibres from cromoglycic acid which has low solubility in water and therefore should not experience significant hygroscopic growth in the airways. Johnson et al. (2000) suggested packing tubular shell particles with an Active Pharmaceutical Ingredient (API) to maximise the per particle dose while targeting distal regions of lungs. Martin and Finlay (2008) have demonstrated the applicability of magnetic field targeting of magnetite-loaded fibres for efficient delivery to specified locations in lungs and encouraged other researchers to develop formulations with fibrous aerosol incorporating chemotherapeutic agents for the treatment of lung cancer.

Dokumenty

BibTex


@proceedings{BUT161044,
  author="František {Lízal} and Matouš {Cabalka} and Milan {Malý} and Árpád {Farkas} and Miloslav {Bělka} and Pavel {Štarha} and Jan {Jedelský} and Miroslav {Jícha}",
  title="Measurement of orientation of fibres in a simplified replica of human trachea under steady conditions",
  annote="Although inhalable fibres are mostly regarded as dangerous and harmful because they are mostly associated with asbestos, several authors have recommended the application of tubular or fibrous particles for drug delivery. Chan and Gonda (1989) were among the first who ventured to enter the unexplored realm of pharmaceutically usable fibres. They prepared fibres from cromoglycic acid which has low solubility in water and therefore should not experience significant hygroscopic growth in the airways. Johnson et al. (2000) suggested packing tubular shell particles with an Active Pharmaceutical Ingredient (API) to maximise the per particle dose while targeting distal regions of lungs. Martin and Finlay (2008) have demonstrated the applicability of magnetic field targeting of magnetite-loaded fibres for efficient delivery to specified locations in lungs and encouraged other researchers to develop formulations with fibrous aerosol incorporating chemotherapeutic agents for the treatment of lung cancer.",
  address="Czech Aerosol Society",
  booktitle="PROCEEDINGS OF 20TH ANNUAL CONFERENCE OF THE CZECH AEROSOL SOCIETY",
  chapter="161044",
  howpublished="online",
  institution="Czech Aerosol Society",
  year="2019",
  month="october",
  publisher="Czech Aerosol Society",
  type="conference proceedings"
}