Detail publikace
Fabrication of novel PHB-liposome nanoparticles and study of their toxicity in vitro
BOKROVÁ, J. MÁROVÁ, I. MATOUŠKOVÁ, P. PAVELKOVÁ, R.
Originální název
Fabrication of novel PHB-liposome nanoparticles and study of their toxicity in vitro
Anglický název
Fabrication of novel PHB-liposome nanoparticles and study of their toxicity in vitro
Jazyk
en
Originální abstrakt
n this work, novel combined PHB-liposome nanoparticles were synthesized and characterized, and their biocompatability with mammalian cells was assessed in vitro. Incorporation of PHB into liposome particles led to preservation of small size (123.8 ± 0.9 nm; evaluated by DLS) and colloidal stability of particles for 2 months in water environment. Cytotoxicity studies using MTT test with two different skin keratinocytes cell lines (HEK and HaCaT) showed significant dose-dependent differences in cell viability after exposure to liposome and PHB liposome particles in vitro.
Anglický abstrakt
n this work, novel combined PHB-liposome nanoparticles were synthesized and characterized, and their biocompatability with mammalian cells was assessed in vitro. Incorporation of PHB into liposome particles led to preservation of small size (123.8 ± 0.9 nm; evaluated by DLS) and colloidal stability of particles for 2 months in water environment. Cytotoxicity studies using MTT test with two different skin keratinocytes cell lines (HEK and HaCaT) showed significant dose-dependent differences in cell viability after exposure to liposome and PHB liposome particles in vitro.
Dokumenty
BibTex
@article{BUT155931,
author="Jitka {Bokrová} and Ivana {Márová} and Petra {Matoušková} and Renata {Pavelková}",
title="Fabrication of novel PHB-liposome nanoparticles and study of their toxicity in vitro",
annote="n this work, novel combined PHB-liposome nanoparticles were synthesized and characterized, and their biocompatability with mammalian cells was assessed in vitro. Incorporation of PHB into liposome particles led to preservation of small size (123.8 ± 0.9 nm; evaluated by DLS) and colloidal stability of particles for 2 months in water environment. Cytotoxicity studies using MTT test with two different skin keratinocytes cell lines (HEK and HaCaT) showed significant dose-dependent differences in cell viability after exposure to liposome and PHB liposome particles in vitro.",
address="Springer Verlag, SRN",
chapter="155931",
doi="10.1007/s11051-019-4484-7",
howpublished="print",
institution="Springer Verlag, SRN",
number="3",
volume="2",
year="2019",
month="february",
pages="3--11",
publisher="Springer Verlag, SRN",
type="journal article in Web of Science"
}