Detail publikace

Simulation of size-dependent aerosol deposition in a realistic model of the upper human airways

Originální název

Simulation of size-dependent aerosol deposition in a realistic model of the upper human airways

Anglický název

Simulation of size-dependent aerosol deposition in a realistic model of the upper human airways

Jazyk

en

Originální abstrakt

An Eulerian internally mixed aerosol model is used for predictions of deposition inside a realistic cast of the human upper airways. The model, formulated in the multi-species and compressible framework, is solved using the sectional discretization of the droplet size distribution function to accurately capture size-dependent aerosol dynamics such as droplet drift, gravitational settling and diffusion. These three mechanisms are implemented in a consistent way in the model, guaranteeing that the total droplet mass as given by the droplet size distribution is always equal to the total droplet mass due to the mass concentration fields. To validate the model, we simulate monodisperse glycerol aerosol deposition inside the lung cast, for which experimental data is available. Provided that an adequate computational mesh is used and an adequate boundary treatment for the inertial deposition velocity, excellent agreement is found with the experimental data. Finally, we study the size-dependent deposition inside the lung cast for a polydisperse aerosol with droplet sizes ranging from the nanometer scale to beyond the micrometer scale. The typical ‘V-shape’ deposition curve is recovered. The aim of this paper is to 1) provide an overview of the Eulerian aerosol dynamics model and method, to 2) validate this method in a relevant complex lung geometry and to 3) explore the capabilities of the method by simulating polydisperse aerosol deposition.

Anglický abstrakt

An Eulerian internally mixed aerosol model is used for predictions of deposition inside a realistic cast of the human upper airways. The model, formulated in the multi-species and compressible framework, is solved using the sectional discretization of the droplet size distribution function to accurately capture size-dependent aerosol dynamics such as droplet drift, gravitational settling and diffusion. These three mechanisms are implemented in a consistent way in the model, guaranteeing that the total droplet mass as given by the droplet size distribution is always equal to the total droplet mass due to the mass concentration fields. To validate the model, we simulate monodisperse glycerol aerosol deposition inside the lung cast, for which experimental data is available. Provided that an adequate computational mesh is used and an adequate boundary treatment for the inertial deposition velocity, excellent agreement is found with the experimental data. Finally, we study the size-dependent deposition inside the lung cast for a polydisperse aerosol with droplet sizes ranging from the nanometer scale to beyond the micrometer scale. The typical ‘V-shape’ deposition curve is recovered. The aim of this paper is to 1) provide an overview of the Eulerian aerosol dynamics model and method, to 2) validate this method in a relevant complex lung geometry and to 3) explore the capabilities of the method by simulating polydisperse aerosol deposition.

BibTex


@article{BUT140968,
  author="E.M.A. {frederix} and Arkadiusz {Kuczaj} and Markus {Nordlund} and Miloslav {Bělka} and František {Lízal} and Jan {Jedelský} and Jakub {Elcner} and Miroslav {Jícha} and B.J. {Geurts}",
  title="Simulation of size-dependent aerosol deposition in a realistic model
of the upper human airways",
  annote="An Eulerian internally mixed aerosol model is used for predictions of deposition inside a realistic
cast of the human upper airways. The model, formulated in the multi-species and compressible
framework, is solved using the sectional discretization of the droplet size distribution function to
accurately capture size-dependent aerosol dynamics such as droplet drift, gravitational settling
and diffusion. These three mechanisms are implemented in a consistent way in the model,
guaranteeing that the total droplet mass as given by the droplet size distribution is always equal
to the total droplet mass due to the mass concentration fields. To validate the model, we simulate
monodisperse glycerol aerosol deposition inside the lung cast, for which experimental data is
available. Provided that an adequate computational mesh is used and an adequate boundary
treatment for the inertial deposition velocity, excellent agreement is found with the experimental
data. Finally, we study the size-dependent deposition inside the lung cast for a polydisperse
aerosol with droplet sizes ranging from the nanometer scale to beyond the micrometer scale. The
typical ‘V-shape’ deposition curve is recovered. The aim of this paper is to 1) provide an overview
of the Eulerian aerosol dynamics model and method, to 2) validate this method in a relevant
complex lung geometry and to 3) explore the capabilities of the method by simulating polydisperse
aerosol deposition.",
  address="ELSEVIER SCI LTD",
  chapter="140968",
  doi="10.1016/j.jaerosci.2017.10.007",
  howpublished="online",
  institution="ELSEVIER SCI LTD",
  number="1",
  volume="115",
  year="2018",
  month="march",
  pages="29--45",
  publisher="ELSEVIER SCI LTD",
  type="journal article"
}