Detail publikace

Reduction of doxorubicin-induced cardiotoxicity using nanocarriers: A review

FOJTŮ, M. GUMULEC, J. STRAČINA, T. RAUDENSKÁ, M. SKOTÁKOVÁ, A. VACULOVIČOVÁ, M. ADAM, V. BABULA, P. NOVÁKOVÁ, M. MASAŘÍK, M.

Originální název

Reduction of doxorubicin-induced cardiotoxicity using nanocarriers: A review

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Background: Anthracycline antibiotic doxorubicin (DOX) is a very potent and extensively prescribed chemotherapeutic drug. It is widely utilized in the therapy of variety of haematological and solid tumours, although its administration is commonly accompanied with several severe side effects. The most serious one is a development of dose-dependent and cumulative cardiotoxicity. In the course of time, many strategies have been investigated in order to avoid or at least to diminish DOX-induced cardiac dysfunction; these include reduction of toxic effect by co-administration with iron chelators (dexrazoxane), trastuzumab, taxanes, statins, and ACE-inhibitors. However, the attenuation of cardiotoxic effect is still not satisfactory yet.

Klíčová slova

Doxorubicin; nanoparticles; liposomal; polymeric; protein; gold; cardiotoxicity; nanocarriers

Autoři

FOJTŮ, M.; GUMULEC, J.; STRAČINA, T.; RAUDENSKÁ, M.; SKOTÁKOVÁ, A.; VACULOVIČOVÁ, M.; ADAM, V.; BABULA, P.; NOVÁKOVÁ, M.; MASAŘÍK, M.

Vydáno

11. 7. 2017

ISSN

1389-2002

Periodikum

CURRENT DRUG METABOLISM

Ročník

18

Číslo

3

Stát

Stát Spojené arabské emiráty

Strany od

237

Strany do

263

Strany počet

27

BibTex

@article{BUT137709,
  author="Michaela {Fojtů} and Jaromír {Gumulec} and Tibor {Stračina} and Martina {Raudenská} and Anna {Skotáková} and Markéta {Vaculovičová} and Vojtěch {Adam} and Petr {Babula} and Marie {Nováková} and Michal {Masařík}",
  title="Reduction of doxorubicin-induced cardiotoxicity using nanocarriers: A review",
  journal="CURRENT DRUG METABOLISM",
  year="2017",
  volume="18",
  number="3",
  pages="237--263",
  doi="10.2174/1389200218666170105165444",
  issn="1389-2002"
}