Detail publikace

Hydrophobic nanodomains in hyaluronan-surfactant system: a fluorescence anisotropy study

HOLÍNKOVÁ, P. MRAVEC, F. PEKAŘ, M.

Originální název

Hydrophobic nanodomains in hyaluronan-surfactant system: a fluorescence anisotropy study

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

This paper deals with the fluorescence anisotropy study of hydrophobic nanodomains formed by interaction between hyaluronan (Hya) and cationic surfactant cetyltrimethylammonium bromide (CTAB) below critical micelle concentration in aqueous solution and the effect of sodium chloride addition to this system. Hyaluronan as negatively charged polyelectrolyte can interact with cationic surfactants via electrostatic interactions to form aggregates, which could be potential used for targeted drug delivery. Two fluorescent probes, which are solubilized in hydrophobic region, were used – perylene and diphenylhexatrien (DPH). The emission spectra, total intensity of fluorescence and steady-state anisotropy of fluorescence in the samples were measured. It was observed that initial addition of CTAB to hyaluronan aqueous solution leads to forming some small hydrophobic domains linked to hyaluronan chains. Then an increasing concentration of CTAB causes phase separation and formation of a condensed phase. Addition of sodium chloride to the samples leads to reorganization of this system – the condensed phase is dissolved and probably free micelles (possibly mixture of micelle linked to hyaluronan chain with free micelle) are formed in the solution.

Klíčová slova

hyaluronan, surfactants, fluorescence spectroscopy, anisotropy

Autoři

HOLÍNKOVÁ, P.; MRAVEC, F.; PEKAŘ, M.

Vydáno

19. 10. 2016

Nakladatel

TANGER Ltd.

Místo

Ostrava

ISBN

978-80-87294-71-0

Kniha

NANOCON 2016 Conference Proceedings

Edice

1st edition, 2017

Strany od

444

Strany do

448

Strany počet

5

BibTex

@inproceedings{BUT137110,
  author="Petra {Holínková} and Filip {Mravec} and Miloslav {Pekař}",
  title="Hydrophobic nanodomains in hyaluronan-surfactant system: a fluorescence anisotropy study
",
  booktitle="NANOCON 2016 Conference Proceedings",
  year="2016",
  series="1st edition, 2017",
  pages="444--448",
  publisher="TANGER Ltd.",
  address="Ostrava",
  isbn="978-80-87294-71-0"
}