Detail publikace

Biological activity of Schiff base peptide complexes

KOPEL, P. MILOSAVLJEVIĆ, V. RICHTERA, L. ADAM, V.

Originální název

Biological activity of Schiff base peptide complexes

Typ

abstrakt

Jazyk

angličtina

Originální abstrakt

Eu(III) and Tb(III) Schiff base complexes are applicable in various fields such as sensing, assays, screening protocols in vitro, and imaging studies in vitro or in vivo. Fluorescent europium and terbium complexes and their interaction with cell penetrating peptide (KKKRKC) can represent an excellent key for understanding pathway of peptide transportation though cell membrane and the application of Schiff base complexes as potential antibacterial drugs. The Schiff base-metal complexes and its conjugates with peptide were tested for their antibacterial activity to assess their inhibiting potential against Pseudomonas aeruginosa and Salmonella typhimurium. Schiff base-metal complexes conjugated with peptide show minor toxicity in normal human PNT1A cells and high antibacterial activity against Pseudomonas aeruginosa and Salmonella typhimurium, where IC50 down to 125.9 muM and/or 36.1 muM were found for Pseudomonas aeruginosa and Salmonella typhimurium, respectively. Our results strongly suggest that Schiff base-metal complexes conjugated with peptide have great potential to be used as effective antibacterial drug.

Klíčová slova

Peptide; Schiff-base; antibacterial drug; Salmonella typhimurium

Autoři

KOPEL, P.; MILOSAVLJEVIĆ, V.; RICHTERA, L.; ADAM, V.

Vydáno

5. 12. 2016

Nakladatel

University of Wroclaw, Faculty of Chemistry

Místo

Karpacz, Poland

ISBN

978-83-60043-31-8

Kniha

XX. International Winter School on Coordination Chemistry

Strany od

3

Strany do

3

Strany počet

1

BibTex

@misc{BUT133595,
  author="Pavel {Kopel} and Vedran {Milosavljević} and Lukáš {Richtera} and Vojtěch {Adam}",
  title="Biological activity of Schiff base peptide complexes",
  booktitle="XX. International Winter School on Coordination Chemistry",
  year="2016",
  pages="3--3",
  publisher="University of Wroclaw, Faculty of Chemistry",
  address="Karpacz, Poland",
  isbn="978-83-60043-31-8",
  note="abstract"
}