Detail publikace

Study of the glass transition of co-amorphous drug by DMA

Originální název

Study of the glass transition of co-amorphous drug by DMA

Anglický název

Study of the glass transition of co-amorphous drug by DMA

Jazyk

en

Originální abstrakt

Nowadays in pharmaceutical research is problem that new chemical entities are poorly water soluble and therefore present a low dissolution rate. One approach to increase their solubility is to convert the crystalline form of a drug into the amorphous form. In this study, the co-amorphous IND-TRY mixtures were prepared by mechanical activation – ball milling. It was given different amount of polyvinylpyrrolidon to the mixture and was characterized. Solid - state properties were analyzed by dynamic mechanical analysis (DMA). It was found that addition of polyvinylpyrrolidon improved stability compared to the pure co-amorphous form. Glass transition state is growing with addition of PVP.

Anglický abstrakt

Nowadays in pharmaceutical research is problem that new chemical entities are poorly water soluble and therefore present a low dissolution rate. One approach to increase their solubility is to convert the crystalline form of a drug into the amorphous form. In this study, the co-amorphous IND-TRY mixtures were prepared by mechanical activation – ball milling. It was given different amount of polyvinylpyrrolidon to the mixture and was characterized. Solid - state properties were analyzed by dynamic mechanical analysis (DMA). It was found that addition of polyvinylpyrrolidon improved stability compared to the pure co-amorphous form. Glass transition state is growing with addition of PVP.

BibTex


@inproceedings{BUT129225,
  author="Irena {Solná} and Tomáš {Solný} and Martina {Klučáková}",
  title="Study of the glass transition of co-amorphous drug by DMA
",
  annote="Nowadays in pharmaceutical research is problem that new chemical entities are poorly
water soluble and therefore present a low dissolution rate. One approach to increase their
solubility is to convert the crystalline form of a drug into the amorphous form.
In this study, the co-amorphous IND-TRY mixtures were prepared by mechanical
activation – ball milling. It was given different amount of polyvinylpyrrolidon to the mixture
and was characterized. Solid - state properties were analyzed by dynamic mechanical analysis
(DMA). It was found that addition of polyvinylpyrrolidon improved stability compared to the
pure co-amorphous form. Glass transition state is growing with addition of PVP.",
  address="MUNI press",
  booktitle="XVI. Workshop of physical chemists and electrochemists Book of abstracts",
  chapter="129225",
  edition="1",
  howpublished="electronic, physical medium",
  institution="MUNI press",
  year="2016",
  month="june",
  pages="212--214",
  publisher="MUNI press",
  type="conference paper"
}