Detail publikace

Cisplatin-resistant prostate cancer model: Differences in antioxidant system, apoptosis and cell cycle

GUMULEC, J. BALVAN, J. SZTALMACHOVÁ, M. RAUDENSKÁ, M. TANHÄUSEROVÁ, V. KNOPFOVÁ, L. POLANSKÁ, H. HUDCOVÁ, K. RUTTKAY-NEDECKÝ, B. BABULA, P. ADAM, V. KIZEK, R. STIBOROVÁ, M. MASAŘÍK, M.

Originální název

Cisplatin-resistant prostate cancer model: Differences in antioxidant system, apoptosis and cell cycle

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Differences in the antioxidant system, apoptotic mechanism and in cell cycle between prostatic cell lines could partially elucidate the development of cisplatin resistance. The aim of this study was to identify the most characteristic parameter for a particular cell line and/or a particular cisplatin treatment using a general regression model and to assess whether it is possible to use measured parameters as markers of cisplatin resistance. This study integrates the results of viability, antioxidant, flow cytometric and quantitative PCR assays in order to characterize the resistance of prostate cancer to cisplatin.

Klíčová slova

prostate cancer, cell cycle, resistance, cisplatin, oxidative stress,

Autoři

GUMULEC, J.; BALVAN, J.; SZTALMACHOVÁ, M.; RAUDENSKÁ, M.; TANHÄUSEROVÁ, V.; KNOPFOVÁ, L.; POLANSKÁ, H.; HUDCOVÁ, K.; RUTTKAY-NEDECKÝ, B.; BABULA, P.; ADAM, V.; KIZEK, R.; STIBOROVÁ, M.; MASAŘÍK, M.

Rok RIV

2014

Vydáno

8. 4. 2014

ISSN

1019-6439

Periodikum

INTERNATIONAL JOURNAL OF ONCOLOGY

Ročník

44

Číslo

3

Stát

Řecká republika

Strany od

923

Strany do

933

Strany počet

11

BibTex

@article{BUT105768,
  author="Jaromír {Gumulec} and Jan {Balvan} and Markéta {Sztalmachová} and Martina {Raudenská} and Veronika {Tanhäuserová} and Lucia {Knopfová} and Hana {Polanská} and Kristýna {Hudcová} and Branislav {Ruttkay-Nedecký} and Petr {Babula} and Vojtěch {Adam} and René {Kizek} and Marie {Stiborová} and Michal {Masařík}",
  title="Cisplatin-resistant prostate cancer model: Differences in antioxidant system, apoptosis and cell cycle",
  journal="INTERNATIONAL JOURNAL OF ONCOLOGY",
  year="2014",
  volume="44",
  number="3",
  pages="923--933",
  doi="10.3892/ijo.2013.2223",
  issn="1019-6439"
}