Detail publikace

Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review

ŠKUTKOVÁ, H. BABULA, P. STIBOROVÁ, M. ECKSCHLAGER, T. TRNKOVÁ, L. PROVAZNÍK, I. HUBÁLEK, J. KIZEK, R. ADAM, V.

Originální název

Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Mammalian metallothioneins (MTs) are cysteine-rich low-molecular mass proteins with numerous functions including toxic metal detoxification, as a metal chaperone and maintenance of metal ion homeostasis. Four major isoforms (MT-1 through MT-4) have been identified in mammals. In this review, the functions of the isoforms are summarized. Moreover, polymorphisms of MTs genes and their connection with cancerogenesis and cancer diagnostics are described. The interesting properties of MTs are closely related with structure, which can be studied by modern bioinformatics approaches and electrochemical methods. The advantages of the mentioned approaches and methods are discussed.

Klíčová slova

Metallothionein; Isoforms; Bioinformatics; Data Analysis; Phylogeny; DNA Sequencing; Electrochemistry; Voltammetry; Brdicka Reaction; Peak H

Autoři

ŠKUTKOVÁ, H.; BABULA, P.; STIBOROVÁ, M.; ECKSCHLAGER, T.; TRNKOVÁ, L.; PROVAZNÍK, I.; HUBÁLEK, J.; KIZEK, R.; ADAM, V.

Rok RIV

2012

Vydáno

1. 12. 2012

ISSN

1452-3981

Periodikum

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE

Ročník

2012

Číslo

7

Stát

Srbská republika

Strany od

12415

Strany do

12431

Strany počet

16

BibTex

@article{BUT96584,
  author="Helena {Vítková} and Petr {Babula} and Marie {Stiborová} and Tomáš {Eckschlager} and Libuše {Trnková} and Valentine {Provazník} and Jaromír {Hubálek} and René {Kizek} and Vojtěch {Adam}",
  title="Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review",
  journal="INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE",
  year="2012",
  volume="2012",
  number="7",
  pages="12415--12431",
  issn="1452-3981"
}