Detail publikace

Sktruktura, polymorfismy a elektrochemické vlastnosti savčích metalotioneinů – Review

ŠKUTKOVÁ, H. BABULA, P. STIBOROVÁ, M. ECKSCHLAGER, T. TRNKOVÁ, L. PROVAZNÍK, I. HUBÁLEK, J. KIZEK, R. ADAM, V.

Originální název

Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review

Český název

Sktruktura, polymorfismy a elektrochemické vlastnosti savčích metalotioneinů – Review

Anglický název

Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review

Typ

článek v časopise

Jazyk

en

Originální abstrakt

Mammalian metallothioneins (MTs) are cysteine-rich low-molecular mass proteins with numerous functions including toxic metal detoxification, as a metal chaperone and maintenance of metal ion homeostasis. Four major isoforms (MT-1 through MT-4) have been identified in mammals. In this review, the functions of the isoforms are summarized. Moreover, polymorphisms of MTs genes and their connection with cancerogenesis and cancer diagnostics are described. The interesting properties of MTs are closely related with structure, which can be studied by modern bioinformatics approaches and electrochemical methods. The advantages of the mentioned approaches and methods are discussed.

Český abstrakt

Metalothioneiny jsou malé na cysteiny bohaté proteiny, které v organismu obstarávají řadu funkcí včetně detoxikace organismu od těžkých kovů. U savců byly identifikovány a popsány čtyři hlavní isoformy MT-1 až MT-4. Tento článek sumarizuje informace dostupné o těchto isoformách a pomocí moderních bioinformatických metod srovnává jejich strukturu a funkci.

Anglický abstrakt

Mammalian metallothioneins (MTs) are cysteine-rich low-molecular mass proteins with numerous functions including toxic metal detoxification, as a metal chaperone and maintenance of metal ion homeostasis. Four major isoforms (MT-1 through MT-4) have been identified in mammals. In this review, the functions of the isoforms are summarized. Moreover, polymorphisms of MTs genes and their connection with cancerogenesis and cancer diagnostics are described. The interesting properties of MTs are closely related with structure, which can be studied by modern bioinformatics approaches and electrochemical methods. The advantages of the mentioned approaches and methods are discussed.

Klíčová slova

Metalotionein; Isoformy; Bioinformatika; Analýza dat; fylogenetika; DNA; Electrochemie; Voltammetrie; Brdičkova Reakce; H pík

Rok RIV

2012

Vydáno

01.12.2012

Strany od

12415

Strany do

12431

Strany počet

16

BibTex


@article{BUT96584,
  author="Helena {Škutková} and Petr {Babula} and Marie {Stiborová} and Tomáš {Eckschlager} and Libuše {Trnková} and Ivo {Provazník} and Jaromír {Hubálek} and René {Kizek} and Vojtěch {Adam}",
  title="Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review",
  annote="Mammalian  metallothioneins (MTs) are cysteine-rich low-molecular mass proteins with numerous 
functions  including toxic metal detoxification, as a metal chaperone and maintenance of metal ion 
homeostasis. Four major isoforms (MT-1 through MT-4) have been identified in mammals.  In this 
review, the functions of the isoforms are summarized. Moreover, polymorphisms of MTs genes and 
their connection with cancerogenesis and cancer diagnostics are described. The interesting properties 
of MTs are closely related with structure, which can be studied by modern bioinformatics approaches 
and electrochemical methods. The advantages of the mentioned approaches and methods are discussed.",
  chapter="96584",
  number="7",
  volume="2012",
  year="2012",
  month="december",
  pages="12415--12431",
  type="journal article"
}