Detail publikace

Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients

Originální název

Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients

Anglický název

Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients

Jazyk

en

Originální abstrakt

Oxidative stress causes profound alterations of various biological structures, including cellular membranes, lipids, proteins and nucleic acids, and it is involved in numerous malignancies. Reduced glutathione (GSH) is considered to be one of the most important scavengers of reactive oxygen species (ROS), and its ratio with oxidised glutathione (GSSG) may be used as a marker of oxidative stress. The main aim of this study was to determine GSH:GSSG ratio in the blood serum of paediatric cancer patients to use this ratio as a potential marker of oxidative stress.

Anglický abstrakt

Oxidative stress causes profound alterations of various biological structures, including cellular membranes, lipids, proteins and nucleic acids, and it is involved in numerous malignancies. Reduced glutathione (GSH) is considered to be one of the most important scavengers of reactive oxygen species (ROS), and its ratio with oxidised glutathione (GSSG) may be used as a marker of oxidative stress. The main aim of this study was to determine GSH:GSSG ratio in the blood serum of paediatric cancer patients to use this ratio as a potential marker of oxidative stress.

BibTex


@article{BUT95487,
  author="Ondřej {Zítka} and Sylvie {Skaličková} and Jaromír {Gumulec} and Michal {Masařík} and Vojtěch {Adam} and Jaromír {Hubálek} and Libuše {Trnková} and René {Kizek}",
  title="Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients",
  annote="Oxidative stress causes profound alterations of various biological structures, including cellular membranes, lipids, proteins and nucleic acids, and it is involved in numerous malignancies. Reduced glutathione (GSH) is considered to be one of the most important scavengers of reactive oxygen species (ROS), and its ratio with oxidised glutathione (GSSG) may be used as a marker of oxidative stress. The main aim of this study was to determine GSH:GSSG ratio in the blood serum of paediatric cancer patients to use this ratio as a potential marker of oxidative stress.",
  address="SPANDIDOS PUBL LTD, POB 18179, ATHENS, 116 10, GREECE",
  chapter="95487",
  doi="10.3892/ol.2012.931",
  institution="SPANDIDOS PUBL LTD, POB 18179, ATHENS, 116 10, GREECE",
  number="4",
  volume="4",
  year="2012",
  month="october",
  pages="1247--1253",
  publisher="SPANDIDOS PUBL LTD, POB 18179, ATHENS, 116 10, GREECE",
  type="journal article in Web of Science"
}