Detail publikace

Study of zinc-dependent aggregation of metallothionein from human prostatic cancer cell lines

Originální název

Study of zinc-dependent aggregation of metallothionein from human prostatic cancer cell lines

Anglický název

Study of zinc-dependent aggregation of metallothionein from human prostatic cancer cell lines

Jazyk

en

Originální abstrakt

Metallothioneins (MTs) are heavy-metal binding cysteine-rich proteins. MTs are thought to play a role in tumour disease. They can be used for studying of course, prognosis and metastating of a tumour. The enhanced MTs expression leads to the formation of cytostatics resistance in tumour cells. One the current accepted opinion is that these mechanisms are closely connected to ability of MT to bind heavy metal ions and form aggregates. The aim of this work was to study the changes in aggregation of MT under various concentrations of zinc and different redox conditions in human prostatic cell lines.

Anglický abstrakt

Metallothioneins (MTs) are heavy-metal binding cysteine-rich proteins. MTs are thought to play a role in tumour disease. They can be used for studying of course, prognosis and metastating of a tumour. The enhanced MTs expression leads to the formation of cytostatics resistance in tumour cells. One the current accepted opinion is that these mechanisms are closely connected to ability of MT to bind heavy metal ions and form aggregates. The aim of this work was to study the changes in aggregation of MT under various concentrations of zinc and different redox conditions in human prostatic cell lines.

BibTex


@misc{BUT93598,
  author="Soňa {Křížková} and Michal {Masařík} and Jaromír {Hubálek} and René {Kizek}",
  title="Study of zinc-dependent aggregation of metallothionein from human prostatic cancer cell lines",
  annote="Metallothioneins (MTs) are heavy-metal binding cysteine-rich proteins. MTs are thought to play a role in tumour disease. They can be used for studying of course, prognosis and metastating of a tumour. The enhanced MTs expression leads to the formation of cytostatics resistance in tumour cells. One the current accepted opinion is that these mechanisms are closely connected to ability of MT to bind heavy metal ions and form aggregates. The aim of this work was to study the changes in aggregation of MT under various concentrations of zinc and different redox conditions in human prostatic cell lines.",
  address="EJC SUPPLEMENTS",
  chapter="93598",
  institution="EJC SUPPLEMENTS",
  number="5",
  year="2010",
  month="july",
  pages="49--49",
  publisher="EJC SUPPLEMENTS",
  type="abstract"
}