Detail publikace

MONITORING OF DNA-DOXORUBICIN INTERACTIONS BY ELECTROCHEMICAL METHODS

HÚSKA, D. KYNCLOVÁ, H. HUBÁLEK, J. BABULA, P. ECKSCHLAGER, T. STIBOROVÁ, M. KIZEK, R.

Originální název

MONITORING OF DNA-DOXORUBICIN INTERACTIONS BY ELECTROCHEMICAL METHODS

Anglický název

MONITORING OF DNA-DOXORUBICIN INTERACTIONS BY ELECTROCHEMICAL METHODS

Jazyk

en

Originální abstrakt

Cancer is presently one of the most studied lifestyle disease. Its treatment is among others based on chemotherapy. One of the drugs used in chemotherapy is doxorubicin, which interacts with DNA and inhibits division of tumour cells. For better usage of this compound as drug, it is necessary to know its interactions with DNA. In work, interactions between doxorubicin and DNA were monitored using electrochemical methods. In addition, intarcalation of doxorubicin into DNA isolated from resistant as well as sentisive tumour cells was monitored and mutual correlation was searched.

Anglický abstrakt

Cancer is presently one of the most studied lifestyle disease. Its treatment is among others based on chemotherapy. One of the drugs used in chemotherapy is doxorubicin, which interacts with DNA and inhibits division of tumour cells. For better usage of this compound as drug, it is necessary to know its interactions with DNA. In work, interactions between doxorubicin and DNA were monitored using electrochemical methods. In addition, intarcalation of doxorubicin into DNA isolated from resistant as well as sentisive tumour cells was monitored and mutual correlation was searched.

Dokumenty

BibTex 


@inproceedings{BUT35163,
  author="Dalibor {Húska} and Hana {Kynclová} and Jaromír {Hubálek} and Petr {Babula} and Tomáš {Eckschlager} and Marie {Stiborová} and René {Kizek}",
  title="MONITORING OF DNA-DOXORUBICIN INTERACTIONS BY ELECTROCHEMICAL METHODS",
  annote="Cancer is presently one of the most studied lifestyle disease. Its treatment is among others based on chemotherapy. One of the drugs used in chemotherapy is doxorubicin, which interacts with DNA and inhibits division of tumour cells. For better usage of this compound as drug, it is necessary to know its interactions with DNA. In work, interactions between doxorubicin and DNA were monitored using electrochemical methods. In addition, intarcalation of doxorubicin into DNA isolated from resistant as well as sentisive tumour cells was monitored and mutual correlation was searched.",
  address="Mendelová univerzita v Brně",
  booktitle="X. Pracovní setkání fyzikálních chemiků a elektrochemiků",
  chapter="35163",
  howpublished="print",
  institution="Mendelová univerzita v Brně",
  year="2010",
  month="june",
  pages="96--98",
  publisher="Mendelová univerzita v Brně",
  type="conference paper"
}