Detail publikace

FireProtASR: Web Server for Fully Automated Ancestral Sequence Reconstruction

MUSIL, M. KHAN, R. BEIER, A. ŠTOURAČ, J. KONEGGER, H. DAMBORSKÝ, J. BEDNÁŘ, D.

Originální název

FireProtASR: Web Server for Fully Automated Ancestral Sequence Reconstruction

Anglický název

FireProtASR: Web Server for Fully Automated Ancestral Sequence Reconstruction

Jazyk

en

Originální abstrakt

There is a great interest in increasing proteins stability to widen their usability in numerous biomedical and biotechnological applications. However, native proteins cannot usually withstand the harsh industrial environment, since they are evolved to function under mild conditions. Ancestral sequence reconstruction is a well-established method for deducing the evolutionary history of genes. Besides its applicability to discover the most probable evolutionary ancestors of the modern proteins, ancestral sequence reconstruction has proven to be a useful approach for the design of highly stable proteins. Recently, several computational tools were developed, which make the ancestral reconstruction algorithms accessible to the community, while leaving the most crucial steps of the preparation of the input data on users side. FireProtASR aims to overcome this obstacle by constructing a fully automated workf low, allowing even the unexperienced users to obtain ancestral sequences based on a sequence query as the only input. FireProtASR is complemented with an interactive, easy-to-use web interface and is freely available at https://loschmidt.chemi.muni.cz/fireprotasr/.

Anglický abstrakt

There is a great interest in increasing proteins stability to widen their usability in numerous biomedical and biotechnological applications. However, native proteins cannot usually withstand the harsh industrial environment, since they are evolved to function under mild conditions. Ancestral sequence reconstruction is a well-established method for deducing the evolutionary history of genes. Besides its applicability to discover the most probable evolutionary ancestors of the modern proteins, ancestral sequence reconstruction has proven to be a useful approach for the design of highly stable proteins. Recently, several computational tools were developed, which make the ancestral reconstruction algorithms accessible to the community, while leaving the most crucial steps of the preparation of the input data on users side. FireProtASR aims to overcome this obstacle by constructing a fully automated workf low, allowing even the unexperienced users to obtain ancestral sequences based on a sequence query as the only input. FireProtASR is complemented with an interactive, easy-to-use web interface and is freely available at https://loschmidt.chemi.muni.cz/fireprotasr/.

Dokumenty

BibTex


@article{BUT168160,
  author="Miloš {Musil} and Rayyan {Khan} and Andy {Beier} and Jan {Štourač} and Hannes {Konegger} and Jiří {Damborský} and David {Bednář}",
  title="FireProtASR: Web Server for Fully Automated Ancestral Sequence Reconstruction",
  annote="There is a great interest in increasing proteins stability to widen their
usability in numerous biomedical and biotechnological applications. However,
native proteins cannot usually withstand the harsh industrial environment, since
they are evolved to function under mild conditions. Ancestral sequence
reconstruction is a well-established method for deducing the evolutionary history
of genes. Besides its applicability to discover the most probable evolutionary
ancestors of the modern proteins, ancestral sequence reconstruction has proven to
be a useful approach for the design of highly stable proteins. Recently, several
computational tools were developed, which make the ancestral reconstruction
algorithms accessible to the community, while leaving the most crucial steps of
the preparation of the input data on users side. FireProtASR aims to overcome
this obstacle by constructing a fully automated workf low, allowing even the
unexperienced users to obtain ancestral sequences based on a sequence query as
the only input. FireProtASR is complemented with an interactive, easy-to-use web
interface and is freely available at
https://loschmidt.chemi.muni.cz/fireprotasr/.",
  address="NEUVEDEN",
  chapter="168160",
  doi="10.1093/bib/bbaa337",
  edition="NEUVEDEN",
  howpublished="online",
  institution="NEUVEDEN",
  number="0000",
  volume="0000",
  year="2020",
  month="april",
  pages="1--11",
  publisher="NEUVEDEN",
  type="journal article - other"
}