Detail publikace

FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends

MELČOVÁ, V. CHALOUPKOVÁ, K. MENČÍK, P. KONTÁROVÁ, S. RAMPICHOVÁ, M. HEDVIČÁKOVÁ, V. SOVKOVÁ, V. PŘIKRYL, R. VOJTOVÁ, L.

Originální název

FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Tissue engineering is a current trend in the regenerative medicine putting pressure on scientists to develop highly functional materials and methods for scaffolds’ preparation. In this paper, the calibrated filaments for Fused Deposition Modeling (FDM) based on plasticized poly(3-hydroxybutyrate)/poly(d,l-lactide) 70/30 blend modified with tricalcium phosphate bioceramics were prepared. Two different plasticizers, Citroflex (n-Butyryl tri-n-hexyl citrate) and Syncroflex (oligomeric adipate ester), both used in the amount of 12 wt%, were compared. The printing parameters for these materials were optimized and the printability was evaluated by recently published warping test. The samples were studied with respect to their thermal and mechanical properties, followed by biological in vitro tests including proliferation, viability, and osteogenic differentiation of human mesenchymal stem cells. According to the results from differential scanning calorimetry and tensile measurements, the Citroflex-based plasticizer showed very good softening effect at the expense of worse printability and unsatisfactory performance during biological testing. On the other hand, the samples with Syncroflex demonstrated lower warping tendency compared to commercial polylactide filament with the warping coefficient one third lower. Moreover, the Syncroflex-based samples exhibited the non-cytotoxicity and promising biocompatibility.

Klíčová slova

additive manufacturing; fused deposition modeling; poly(3-hydroxybutyrate); polylactide; tricalcium phosphate; regenerative medicine; tissue engineering; bone scaffolds

Autoři

MELČOVÁ, V.; CHALOUPKOVÁ, K.; MENČÍK, P.; KONTÁROVÁ, S.; RAMPICHOVÁ, M.; HEDVIČÁKOVÁ, V.; SOVKOVÁ, V.; PŘIKRYL, R.; VOJTOVÁ, L.

Vydáno

27. 11. 2020

Nakladatel

MDPI

Místo

Basel

ISSN

2073-4360

Periodikum

Polymers

Ročník

12

Číslo

12

Stát

Švýcarská konfederace

Strany od

1

Strany do

19

Strany počet

19

URL

https://www.mdpi.com/2073-4360/12/12/2806

Plný text v Digitální knihovně

http://hdl.handle.net/11012/195767

BibTex

@article{BUT166290,
  author="Veronika {Melčová} and Kateřina {Chaloupková} and Přemysl {Menčík} and Soňa {Kontárová} and Michaela {Rampichová} and Věra {Hedvičáková} and Věra {Sovková} and Radek {Přikryl} and Lucy {Vojtová}",
  title="FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends",
  journal="Polymers",
  year="2020",
  volume="12",
  number="12",
  pages="1--19",
  doi="10.3390/polym12122806",
  issn="2073-4360",
  url="https://www.mdpi.com/2073-4360/12/12/2806"
}

Dokumenty

Melcova_ FDM 3D Printed Composites for Bone Tissue Engineering_2021.zip
Polymers_12-02806.pdf