Detail publikace

Hyaluronan Biofilms Reinforced with Partially Deacetylated Chitin Nanowhiskers: Extraction, Fabrication, In-vitro and Antibacterial Properties of Advanced Nanocomposites

Originální název

Hyaluronan Biofilms Reinforced with Partially Deacetylated Chitin Nanowhiskers: Extraction, Fabrication, In-vitro and Antibacterial Properties of Advanced Nanocomposites

Anglický název

Hyaluronan Biofilms Reinforced with Partially Deacetylated Chitin Nanowhiskers: Extraction, Fabrication, In-vitro and Antibacterial Properties of Advanced Nanocomposites

Jazyk

en

Originální abstrakt

Fabrication of nanocomposite biofilms with enhanced mechanical and antibacterial properties was successfully achieved from hyaluronan (HA) and partially deacetylated chitin nanowhiskers (ChNWs) by a casting-evaporation method. The hydrolysis process of chitin showed an important role in the dimensions, stability, and the crystallinity of extracted ChNWs in a timedependent manner. The volume fraction of ChNWs nanofiller varying from (0.001 to 0.5) exhibited a great influence on the mechanical properties of the biofilms (young modulus, strength) was enhanced by the high load-bearing capacity of NWs compared with net HA film. The antibacterial activity of the nanocomposite biofilms exhibited significant bactericidal activity against different types of bacteria (-/+ gram). HA/ChNWs Nanocomposite biofilms did not show any toxicity against normal human dermal fibroblasts (NHDF) and human primary osteogenic sarcoma (Saos-2) cell lines. The new biofilms with unique properties like edibleness, environmental friendliness, high mechanical properties, antibacterial performance, and noncytotoxicity that could be used in skin/bone tissue regenerations, and drug delivery applications.

Anglický abstrakt

Fabrication of nanocomposite biofilms with enhanced mechanical and antibacterial properties was successfully achieved from hyaluronan (HA) and partially deacetylated chitin nanowhiskers (ChNWs) by a casting-evaporation method. The hydrolysis process of chitin showed an important role in the dimensions, stability, and the crystallinity of extracted ChNWs in a timedependent manner. The volume fraction of ChNWs nanofiller varying from (0.001 to 0.5) exhibited a great influence on the mechanical properties of the biofilms (young modulus, strength) was enhanced by the high load-bearing capacity of NWs compared with net HA film. The antibacterial activity of the nanocomposite biofilms exhibited significant bactericidal activity against different types of bacteria (-/+ gram). HA/ChNWs Nanocomposite biofilms did not show any toxicity against normal human dermal fibroblasts (NHDF) and human primary osteogenic sarcoma (Saos-2) cell lines. The new biofilms with unique properties like edibleness, environmental friendliness, high mechanical properties, antibacterial performance, and noncytotoxicity that could be used in skin/bone tissue regenerations, and drug delivery applications.

BibTex


@article{BUT162034,
  author="Rasha {Abdelrahman} and Abdelmohsan {Abdellatif} and Marek {Zbončák} and Petr {Lepcio} and Josef {Jančář}",
  title="Hyaluronan Biofilms Reinforced with Partially Deacetylated Chitin Nanowhiskers:
Extraction, Fabrication, In-vitro and Antibacterial Properties of Advanced Nanocomposites",
  annote="Fabrication of nanocomposite biofilms with enhanced mechanical and antibacterial
properties was successfully achieved from hyaluronan (HA) and partially deacetylated chitin
nanowhiskers (ChNWs) by a casting-evaporation method. The hydrolysis process of chitin showed
an important role in the dimensions, stability, and the crystallinity of extracted ChNWs in a timedependent manner. The volume fraction of ChNWs nanofiller varying from (0.001 to 0.5)
exhibited a great influence on the mechanical properties of the biofilms (young modulus, strength)
was enhanced by the high load-bearing capacity of NWs compared with net HA film. The
antibacterial activity of the nanocomposite biofilms exhibited significant bactericidal activity
against different types of bacteria (-/+ gram). HA/ChNWs Nanocomposite biofilms did not show
any toxicity against normal human dermal fibroblasts (NHDF) and human primary osteogenic
sarcoma (Saos-2) cell lines. The new biofilms with unique properties like edibleness,
environmental friendliness, high mechanical properties, antibacterial performance, and noncytotoxicity that could be used in skin/bone tissue regenerations, and drug delivery applications.",
  chapter="162034",
  number="12",
  volume="244",
  year="2020",
  month="february",
  pages="115951--115963",
  type="journal article in Web of Science"
}