Detail publikace

The Effect of the Thermosensitive Biodegradable PLGA–PEG–PLGA Copolymer on the Rheological, Structural and Mechanical Properties of Thixotropic Self-Hardening Tricalcium Phosphate Cement

VOJTOVÁ, L. MICHLOVSKÁ, L. VALOVÁ, K. ZBONČÁK, M. TRUNEC, M. ČÁSTKOVÁ, K. KRTIČKA, M. PAVLIŇÁKOVÁ, V. POLÁČEK, P. DZUROV, M. LUKÁŠOVÁ, V. RAMPICHOVÁ, M. SUCHÝ, T. SEDLÁČEK, R. GINEBRA, M. MONTUFAR JIMENEZ, E.

Originální název

The Effect of the Thermosensitive Biodegradable PLGA–PEG–PLGA Copolymer on the Rheological, Structural and Mechanical Properties of Thixotropic Self-Hardening Tricalcium Phosphate Cement

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

The current limitations of calcium phosphate cements (CPCs) used in the field of bone regeneration consist of their brittleness, low injectability, disintegration in body fluids and low biodegradability. Moreover, no method is currently available to measure the setting time of CPCs in correlation with the evolution of the setting reaction. The study proposes that it is possible to improve and tune the properties of CPCs via the addition of a thermosensitive, biodegradable, thixotropic copolymer based on poly(lactic acid), poly(glycolic acid) and poly(ethylene glycol) (PLGA-PEG-PLGA) which undergoes gelation under physiological conditions. The setting times of alpha-tricalcium phosphate (-TCP) mixed with aqueous solutions of PLGA-PEG-PLGA determined by means of time-sweep curves revealed a lag phase during the dissolution of the -TCP particles. The magnitude of the storage modulus at lag phase depends on the liquid to powder ratio, the copolymer concentration and temperature. A sharp increase in the storage modulus was observed at the time of the precipitation of calcium deficient hydroxyapatite (CDHA) crystals, representing the loss of paste workability. The PLGA-PEG-PLGA copolymer demonstrates the desired pseudoplastic rheological behaviour with a small decrease in shear stress and the rapid recovery of the viscous state once the shear is removed, thus preventing CPC phase separation and providing good cohesion. Preliminary cytocompatibility tests performed on human mesenchymal stem cells proved the suitability of the novel copolymer/-TCP for the purposes of mini-invasive surgery.

Klíčová slova

injectable bone cements; thixotropic; rheology; morphology; kinetics; biocompatibility

Autoři

VOJTOVÁ, L.; MICHLOVSKÁ, L.; VALOVÁ, K.; ZBONČÁK, M.; TRUNEC, M.; ČÁSTKOVÁ, K.; KRTIČKA, M.; PAVLIŇÁKOVÁ, V.; POLÁČEK, P.; DZUROV, M.; LUKÁŠOVÁ, V.; RAMPICHOVÁ, M.; SUCHÝ, T.; SEDLÁČEK, R.; GINEBRA, M.; MONTUFAR JIMENEZ, E.

Vydáno

17. 1. 2019

Nakladatel

MDPI

Místo

Basel, Switzerland

ISSN

1422-0067

Periodikum

International Journal of Molecular Sciences

Ročník

20

Číslo

2

Stát

Švýcarská konfederace

Strany od

1

Strany do

21

Strany počet

21

URL

Plný text v Digitální knihovně

BibTex

@article{BUT155140,
  author="Lucy {Vojtová} and Lenka {Michlovská} and Kristýna {Hlináková} and Marek {Zbončák} and Martin {Trunec} and Klára {Částková} and Milan {Krtička} and Veronika {Pavliňáková} and Petr {Poláček} and Matej {Dzurov} and Věra {Lukášová} and Michala {Rampichová} and Tomáš {Suchý} and Radek {Sedláček} and Maria-Pau {Ginebra} and Edgar Benjamin {Montufar Jimenez}",
  title="The Effect of the Thermosensitive Biodegradable PLGA–PEG–PLGA Copolymer on the Rheological, Structural and Mechanical Properties of Thixotropic Self-Hardening Tricalcium Phosphate Cement",
  journal="International Journal of Molecular Sciences",
  year="2019",
  volume="20",
  number="2",
  pages="1--21",
  doi="10.3390/ijms20020391",
  issn="1422-0067",
  url="http://www.mdpi.com/1422-0067/20/2/391"
}