Detail publikace

Comparison of Mathematical and Controlled Mechanical Lung Simulation in Active Breathing and Ventilated State

PAŠTĚKA, R. FORJAN, M. DRAUSCHKE, A.

Originální název

Comparison of Mathematical and Controlled Mechanical Lung Simulation in Active Breathing and Ventilated State

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

Respiratory diseases are ubiquitous among European citizens and their prevalence is increasing steadily. Deeper insight into the respiratory process can be gained by modelling of the region of interest in the human body. The presented lung simulator xPULM bridges the gap between in-silico (mathematical), in-vivo (cell culture based) and mechanical models of the respiratory tract. By adopting selected mathematical models of the human respiratory tract two scenarios were simulated. The linear mathematical single compartment model was used for simulation of the human breathing pattern at rest. Higher complexity non-linear mathematical model reflecting diverse nature of the human respiratory tract was used as a basis for simulation of an artificially ventilated patient. The time-flow characteristics of the mathematical models have been implemented into the control software of the mechanical lung simulator - xPULM. The simulator was then configured to replicate these required breathing patterns employing feedback control loop. The airflow was measured over the course of breathing simulation. The results show high conformity of required and measured breathing patterns characteristic with steady frequency rate and minimal airflow variability. Furthermore, xPULM was capable of reproducing rapid changes of airflow occurring during simulation of artificially ventilated patient, showing high versatility and adaptability of the simulator. Future research will focus on reduction of flow fluctuations and implementation of new breathing patterns. (C) 2018, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

Klíčová slova

Breathing simulation, mathematical models, in-silico models, flow measurement, mechanical simulation, artificial ventilation, feedback control loop

Autoři

PAŠTĚKA, R.; FORJAN, M.; DRAUSCHKE, A.

Vydáno

21. 4. 2018

ISSN

2405-8963

Periodikum

IFAC-PapersOnLine (ELSEVIER)

Ročník

1

Číslo

1

Stát

Nizozemsko

Strany od

42

Strany do

47

Strany počet

6

BibTex

@inproceedings{BUT147315,
  author="Richard {Paštěka} and Mathias {Forjan} and Andreas {Drauschke}",
  title="Comparison of Mathematical and Controlled Mechanical Lung Simulation in Active Breathing and Ventilated State",
  booktitle="Proceedings of the 15th IFAC Conference on Programmable Devices and Embedded Systems PDeS 2018",
  year="2018",
  journal="IFAC-PapersOnLine (ELSEVIER)",
  volume="1",
  number="1",
  pages="42--47",
  doi="10.1016/j.ifacol.2018.07.127",
  issn="2405-8963"
}