Detail publikace

Evaluation of an Active Lung Simulator for Aerosol Inhalation Test Replacement

PAŠTĚKA, R. FORJAN, M.

Originální název

Evaluation of an Active Lung Simulator for Aerosol Inhalation Test Replacement

Typ

abstrakt

Jazyk

angličtina

Originální abstrakt

Aerosols are a ubiquitous part of the surrounding environment. Airborne particles may be produced by intention, as several spray-based cosmetics, but are not intended to be inhaled. The number of deposited particles in the lung tissue can only be estimated using mathematical models or simplified organ models. However, the question of actually deposited particles remains. The presented active lung simulator, i-Lung, has been designed to enable active inand exhalation and live measurement of environmental aerosols with a particle size distribution of 0.2 μm - 40 μm, representing respirable and inhalable aerosols. The i-Lung simulates an active spontaneously breathing human lung by changing the pressure within the housing of the different applicable lung equivalents as Latex bags or porcine lungs. An extracorporeal perfusion circuit, based on human lung transplantation techniques, is developed alongside and is supposed to nourish porcine lungs, taken from the slaughtering process.

Klíčová slova

Aerosol measurements, mechanical lung simulator, respiratory system model

Autoři

PAŠTĚKA, R.; FORJAN, M.

Vydáno

24. 8. 2017

Nakladatel

ALTEX

Místo

Kuesnacht, Switzerland

ISSN

2194-0479

Periodikum

ALTEX proceedings

Ročník

6

Číslo

1

Stát

Švýcarská konfederace

Strany od

47

Strany do

48

Strany počet

1

URL

http://www.altex.ch/altex-proceedings/wc-10-seattle

BibTex

@misc{BUT138970,
  author="PAŠTĚKA, R. and FORJAN, M.",
  title="Evaluation of an Active Lung Simulator for Aerosol Inhalation Test Replacement",
  booktitle="Alternatives and Animal Use in the Life Sciences: 3Rs in Action, Seattle, Washington, August 2017",
  year="2017",
  journal="ALTEX proceedings",
  volume="6",
  number="1",
  pages="47--48",
  publisher="ALTEX",
  address="Kuesnacht, Switzerland",
  issn="2194-0479",
  url="http://www.altex.ch/altex-proceedings/wc-10-seattle",
  note="abstract"
}