Detail publikace

Characteristics of synovial fluid required for optimization of lubrication fluid for biotribological experiments

GALANDÁKOVÁ, A. ULRICHOVÁ, J. LANGOVÁ, K. HANÁKOVÁ, A. VRBKA, M. HARTL, M. GALLO, J.

Originální název

Characteristics of synovial fluid required for optimization of lubrication fluid for biotribological experiments

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Wear testing of total joint replacement (TJR) is mandatory in preclinical testing before implantation of TJR into the human body. Testing is governed by current international standards that recommend bovine serum (BS) as a lubricating fluid to replace synovial fluid (SF). Recently, the use of BS has been criticized because of differences in content, fluid characteristics, and nonhuman origin. As a result, a more realistic lubricant mimicking SF is needed. To define SF composition, we analyzed SF obtained during revisions of total hip and knee arthroplasties and compared it with SF obtained during primary arthroplasties and from patients without TJR. Samples were acquired from 152 patients. We found that the median total protein concentration for all SF was 36.8 mg/mL, which is significantly higher than concentrations currently recommended by the ISO standards. The gama globulin concentration was significantly higher and the phospholipid concentration significantly lower in patients with revision of TJR compared with patients without TJR. No significant difference was found in hyaluronic acid concentration and viscosity among the groups. Our results support the need to improve the definition of a more clinically relevant wear testing lubricant in the ISO standards.

Klíčová slova

total hip and knee replacement, protein, hyaluronic acid, phospholipid, viscosity

Autoři

GALANDÁKOVÁ, A.; ULRICHOVÁ, J.; LANGOVÁ, K.; HANÁKOVÁ, A.; VRBKA, M.; HARTL, M.; GALLO, J.

Vydáno

18. 4. 2016

Nakladatel

John Wiley & Sons Inc.

Místo

USA

ISSN

1552-4981

Periodikum

Journal of biomedical materials research. Part B, Applied biomaterials (Electronic)

Ročník

105

Číslo

6

Stát

Spojené státy americké

Strany od

1422

Strany do

1431

Strany počet

10

URL

http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33663/full

BibTex

@article{BUT126663,
  author="GALANDÁKOVÁ, A. and ULRICHOVÁ, J. and LANGOVÁ, K. and HANÁKOVÁ, A. and VRBKA, M. and HARTL, M. and GALLO, J.",
  title="Characteristics of synovial fluid required for optimization of lubrication fluid for biotribological experiments",
  journal="Journal of biomedical materials research. Part B, Applied biomaterials (Electronic)",
  year="2016",
  volume="105",
  number="6",
  pages="1422--1431",
  doi="10.1002/jbm.b.33663",
  issn="1552-4981",
  url="http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33663/full"
}