Detail publikace

Interictal high-frequency oscillations in focal human epilepsy

Originální název

Interictal high-frequency oscillations in focal human epilepsy

Anglický název

Interictal high-frequency oscillations in focal human epilepsy

Jazyk

en

Originální abstrakt

Purpose of review Localization of focal epileptic brain is critical for successful epilepsy surgery and focal brain stimulation. Despite significant progress, roughly half of all patients undergoing focal surgical resection, and most patients receiving focal electrical stimulation, are not seizure free. There is intense interest in high-frequency oscillations (HFOs) recorded with intracranial electroencephalography as potential biomarkers to improve epileptogenic brain localization, resective surgery, and focal electrical stimulation. The present review examines the evidence that HFOs are clinically useful biomarkers. Recent findings Performing the PubMed search ‘High-Frequency Oscillations and Epilepsy’ for 2013–2015 identifies 308 articles exploring HFO characteristics, physiological significance, and potential clinical applications. Summary There is strong evidence that HFOs are spatially associated with epileptic brain. There remain, however, significant challenges for clinical translation of HFOs as epileptogenic brain biomarkers: Differentiating true HFO from the high-frequency power changes associated with increased neuronal firing and bandpass filtering sharp transients. Distinguishing pathological HFO from normal physiological HFO. Classifying tissue under individual electrodes as normal or pathological. Sharing data and algorithms so research results can be reproduced across laboratories. Multicenter prospective trials to provide definitive evidence of clinical utility. Keywords biomarker, electroencephalography, epilepsy, high-frequency oscillation

Anglický abstrakt

Purpose of review Localization of focal epileptic brain is critical for successful epilepsy surgery and focal brain stimulation. Despite significant progress, roughly half of all patients undergoing focal surgical resection, and most patients receiving focal electrical stimulation, are not seizure free. There is intense interest in high-frequency oscillations (HFOs) recorded with intracranial electroencephalography as potential biomarkers to improve epileptogenic brain localization, resective surgery, and focal electrical stimulation. The present review examines the evidence that HFOs are clinically useful biomarkers. Recent findings Performing the PubMed search ‘High-Frequency Oscillations and Epilepsy’ for 2013–2015 identifies 308 articles exploring HFO characteristics, physiological significance, and potential clinical applications. Summary There is strong evidence that HFOs are spatially associated with epileptic brain. There remain, however, significant challenges for clinical translation of HFOs as epileptogenic brain biomarkers: Differentiating true HFO from the high-frequency power changes associated with increased neuronal firing and bandpass filtering sharp transients. Distinguishing pathological HFO from normal physiological HFO. Classifying tissue under individual electrodes as normal or pathological. Sharing data and algorithms so research results can be reproduced across laboratories. Multicenter prospective trials to provide definitive evidence of clinical utility. Keywords biomarker, electroencephalography, epilepsy, high-frequency oscillation

BibTex


@article{BUT125393,
  author="Jan {Cimbálník} and Michal T. {Kucewicz} and Gregory {Worrell}",
  title="Interictal high-frequency oscillations in focal human epilepsy",
  annote="Purpose of review Localization of focal epileptic brain is critical for successful epilepsy surgery and focal brain stimulation. Despite significant progress, roughly half of all patients undergoing focal surgical resection, and most patients receiving focal electrical stimulation, are not seizure free. There is intense interest in high-frequency oscillations (HFOs) recorded with intracranial electroencephalography as potential biomarkers to improve epileptogenic brain localization, resective surgery, and focal electrical stimulation. The present review examines the evidence that HFOs are clinically useful biomarkers. Recent findings Performing the PubMed search ‘High-Frequency Oscillations and Epilepsy’ for 2013–2015 identifies 308 articles exploring HFO characteristics, physiological significance, and potential clinical applications. Summary There is strong evidence that HFOs are spatially associated with epileptic brain. There remain, however, significant challenges for clinical translation of HFOs as epileptogenic brain biomarkers: Differentiating true HFO from the high-frequency power changes associated with increased neuronal firing and bandpass filtering sharp transients. Distinguishing pathological HFO from normal physiological HFO. Classifying tissue under individual electrodes as normal or pathological. Sharing data and algorithms so research results can be reproduced across laboratories. Multicenter prospective trials to provide definitive evidence of clinical utility. Keywords biomarker, electroencephalography, epilepsy, high-frequency oscillation",
  chapter="125393",
  doi="10.1097/WCO.0000000000000302",
  howpublished="online",
  number="2",
  volume="29",
  year="2016",
  month="february",
  pages="175--181",
  type="journal article"
}